Evidence map›Paper›PMID 30498820›Full record

ArticleThe journal of nutrition, health & aging2018

International Clinical Practice Guidelines for Sarcopenia (ICFSR): Screening, Diagnosis and Management.

E Dent, J E Morley, A J Cruz-Jentoft, H Arai, S B Kritchevsky, J Guralnik, J M Bauer, M Pahor, B C Clark, M Cesari and 28 more

7 registry-linked trialsOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of nutrition, health & aging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 7 registered trials, which are not on this map. Cited by 621 papers, 20 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
621citing papers in PubMed, 20 pooled it
41.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04948736 nacompletednot on this mapstarted 2022, after this paper: background citation

Effectiveness and Clinical Application of Multidisciplinary Combined Exercise and Nutrition Intervention for Sarcopenic Older Adults With Metabolic Syndrome: Multicenter Randomized Controlled Trial

TypeinterventionalSponsorSeoul National University Bundang HospitalRan2022 to 2025Enrolled168ConditionsSarcopeniaArmsCombined exercise and nutrition intervention, Conventional medial care
NCT05790863 nacompletednot on this mapstarted 2023, after this paper: background citation

Effects of Low-volume High-intensity Training Versus Moderate-intensity Continuous Training on Physical Performance in Older Adults With Possible Sarcopenia

TypeinterventionalSponsorThe Hong Kong Polytechnic UniversityRan2023 to 2024Enrolled30ConditionsSarcopeniaArmsErgometer cycling
NCT06049914 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Combined Exercise and Nutrition Intervention for Possible Sarcopenia Among Community-dwelling Older Adults in Primary Care: A Randomized Controlled Trial

TypeinterventionalSponsorKyunghee University Medical CenterRan2023 to 2024Enrolled94ConditionsSarcopeniaArmsExperimental group
NCT06149871 nacompletednot on this mapstarted 2021, after this paper: background citation

Effectiveness of Individual Physical Activity Programs to Prevent and Slow Progression of Sarcopenia and Frailty Among Thai Community-dwelling Older Adults: A Double-blind Randomized Clinical Trial

TypeinterventionalSponsorMinistry of Health, ThailandRan2021 to 2022Enrolled360ConditionsSarcopenia, FrailtyArmsPhysical activity
NCT06654648 narecruitingnot on this mapstarted 2022, after this paper: background citation

Combined Exercise and Nutrition Intervention for Sarcopenia in Patients With Hip Fracture: CENTERS； A Multicenter Randomized Controlled Trial

TypeinterventionalSponsorSeoul Bumin HospitalRan2022 to 2024Enrolled118ConditionsSarcopeniaArmsCombined exercise nutrition intervention group, Conventional medial care group
NCT07028294 nacompletednot on this mapstarted 2023, after this paper: background citation

Effectiveness and Clinical Application of Multidisciplinary Combined Exercise and Nutrition Intervention for Sarcopenic Older Adults With Metabolic Syndrome: Multicenter Empirical Study

TypeinterventionalSponsorSeoul National University Bundang HospitalRan2023 to 2025Enrolled80ConditionsSarcopeniaArmsCombined exercise and nutrition intervention
NCT07356440 naactive not recruitingnot on this mapstarted 2025, after this paper: background citation

Effect of Consumption of Vegetable Protein-enriched Biscuits and Vitamin D Supplementation on the Progression of Sarcopenia in Elderly Subjects

TypeinterventionalSponsorUniversity of UdineRan2025 to 2026Enrolled74ConditionsSarcopenia in Elderly, Sarcopenia, Nutritional Intervention, Microbiome AnalysisArmsVitamin D3 supplement, Protein-enriched biscuits, Control biscuit, Placebo oil
3 · Its place in the literature

Who cites it

621 citing papers in PubMed, 20 syntheses or guidelines pooled it, 1,036 citations in OpenAlex.

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561 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

38 authors at 20 institutions in 18 countries.

E DentDr. Elsa Dent, elsa.dent@adelaide.edu.au, Torrens University Australia, Wakefield Street, Adelaide, SA, Australia.
J E Morley
A J Cruz-Jentoft
H Arai
S B Kritchevsky
J Guralnik
J M Bauer
M Pahor
B C Clark
M Cesari
J Ruiz
C C Sieber
M Aubertin-Leheudre
D L Waters
R Visvanathan
F Landi
D T Villareal
R Fielding
C W Won
O Theou
F C Martin
B Dong
J Woo
L Flicker
L Ferrucci
R A Merchant
L Cao
T Cederholm
S M L Ribeiro
L Rodríguez-Mañas
S D Anker
J Lundy
L M Gutiérrez Robledo
I Bautmans
I Aprahamian
J M G A Schols
M Izquierdo
B Vellas
Agaplesion Bethanien Krankenhaus · DEChinese University of Hong Kong · HKDalhousie University · CAFaculdade de Medicina de Jundiaí · BRFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITFriedrich-Alexander-Universität Erlangen-Nürnberg · DEHospital Universitario de Getafe · ESInstitute on Aging · USInstituto Ramón y Cajal de Investigación Sanitaria · ESKing's College London · GBKyung Hee University · KRMaastricht University · NLMédipole Garonne · FRMemorial Hospital · USMichael E. DeBakey VA Medical Center · USNational Center for Geriatrics and Gerontology · JPNational University Health System · SGNavarrabiomed · ESSaint Louis University · USSichuan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesSarcopenia, defined as an age-associated loss of skeletal muscle function and muscle mass, occurs in approximately 6 - 22 % of older adults. This paper presents evidence-based clinical practice guidelines for screening, diagnosis and management of sarcopenia from the task force of the International Conference on Sarcopenia and Frailty Research (ICSFR).

methodsTo develop the guidelines, we drew upon the best available evidence from two systematic reviews paired with consensus statements by international working groups on sarcopenia. Eight topics were selected for the recommendations: (i) defining sarcopenia; (ii) screening and diagnosis; (iii) physical activity prescription; (iv) protein supplementation; (v) vitamin D supplementation; (vi) anabolic hormone prescription; (vii) medications under development; and (viii) research. The ICSFR task force evaluated the evidence behind each topic including the quality of evidence, the benefit-harm balance of treatment, patient preferences/values, and cost-effectiveness. Recommendations were graded as either strong or conditional (weak) as per the GRADE (Grading of Recommendations Assessment, Development and Evaluation) approach. Consensus was achieved via one face-to-face workshop and a modified Delphi process. RECOMMENDATIONS: We make a conditional recommendation for the use of an internationally accepted measurement tool for the diagnosis of sarcopenia including the EWGSOP and FNIH definitions, and advocate for rapid screening using gait speed or the SARC-F. To treat sarcopenia, we strongly recommend the prescription of resistance-based physical activity, and conditionally recommend protein supplementation/a protein-rich diet. No recommendation is given for Vitamin D supplementation or for anabolic hormone prescription. There is a lack of robust evidence to assess the strength of other treatment options.

Indexed as

AgedAged, 80 and overFemaleHumansMaleMass ScreeningSarcopenia80 and overagedmuscle strengthpractice guidelineSarcopenia diagnosissarcopenia therapy

Identifiers

PMID30498820
PMCPMC12280515
OpenAlexW2901294932

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

and 1 more above

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.