ArticleNature human behaviour2018
Functional Alignment with Anatomical Networks is Associated with Cognitive Flexibility.
Article in Nature human behaviour, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
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Who cites it
95 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Population-Level Age Effects on the White Matter Structure Subserving Cognitive Flexibility in the Human Brain.eNeuro · 2026Pooled it
- A meta-analysis of cognitive flexibility in aging: Perspective from functional network and lateralization.Human brain mapping · 2024Pooled it
- Brain structural and functional connectivity converge prenatally but diverge after birth.PLoS biology · 2026Article
- A reproducible low-dimensional architecture of human white-matter connectivity.Research square · 2026Article
- Spectral organization of individualized connectome harmonics across brain structure, function and cognition.bioRxiv : the preprint server for biology · 2026Article
- Multiscale structural connectome eigenmodes constrain human brain functional dynamics.Communications biology · 2026Article
- Mapping Whole-Brain Nonlinear Structure-Function Dynamics in Aging via Neural Granger Causality.Brain topography · 2026Article
- DTI-ALPS and subcortical structural-functional coupling mediate the impact of sleep quality on working memory in insomnia disorder.Psychological medicine · 2026Article
- Variations of structural-functional coupling in post-traumatic stress disorder are associated with underlying molecular and transcriptional features.Psychological medicine · 2026Article
- Opportunities and pitfalls of data contextualization in neuroimaging.Nature reviews. Neuroscience · 2026Review
- A walk-sum framework of frequency-dependent brain communication architecture.bioRxiv : the preprint server for biology · 2026Article
- Altered salience network structure-function integration underlies the decline in cognitive flexibility during aging.PLoS biology · 2026Article
- Alterations in brain structure-function coupling associated with musical training.Frontiers in human neuroscience · 2026Article
- A Dimensionality Reduction Approach for Motor Imagery Brain-Computer Interface Using Functional Clustering and Graph Signal Processing.Journal of medical signals and sensors · 2026Article
- The applicability of a cueing paradigm to study individual differences in the spotlight of attention.Attention, perception & psychophysics · 2025Article
- White matter structure-function coupling alteration is associated with plasma biomarkers and cognition in Alzheimer's disease.European radiology · 2025Article
- Alterations of structural-functional connectivity coupling in older adults with depressive symptoms.Psychological medicine · 2025Article
- Disrupted Structure-Function Integration in Systemic Lupus Erythematosus and Its Impact on Cognitive Flexibility.Human brain mapping · 2025Article
- How to Improve Cognitive Flexibility: Evidence From Noninvasive Neuromodulation Techniques.CNS neuroscience & therapeutics · 2025Review
- Large-scale comparative analysis reveals top graph signal processing features for subject identification.bioRxiv : the preprint server for biology · 2025Article
35 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Cognitive flexibility describes the human ability to switch between modes of mental function to achieve goals. Mental switching is accompanied by transient changes in brain activity, which must occur atop an anatomical architecture that bridges disparate cortical and subcortical regions by underlying white matter tracts. However, an integrated perspective regarding how white matter networks might constrain brain dynamics during cognitive processes requiring flexibility has remained elusive. To address this challenge, we applied emerging tools from graph signal processing to examine whether BOLD signals measured at each point in time correspond to complex underlying anatomical networks in 28 individuals performing a perceptual task that probed cognitive flexibility. We found that the alignment between functional signals and the architecture of the underlying white matter network was associated with greater cognitive flexibility across subjects. By computing a concise measure using multi-modal neuroimaging data, we uncovered an integrated structure-function correlate of human behavior.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.