Evidence map›Paper›PMID 30498580›Full record

ArticleMolecular systems design & engineering2017

Targeted drug delivery using iRGD peptide for solid cancer treatment.

Xiangsheng Liu, Jinhong Jiang, Ying Ji, Jianqin Lu, Ryan Chan, Huan Meng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular systems design & engineering, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 55 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Xiangsheng LiuDepartment of Medicine, Division of NanoMedicine, University of California, Los Angeles, CA, USA.
Jinhong JiangDepartment of Medicine, Division of NanoMedicine, University of California, Los Angeles, CA, USA.
Ying JiDepartment of Medicine, Division of NanoMedicine, University of California, Los Angeles, CA, USA.
Jianqin LuDepartment of Medicine, Division of NanoMedicine, University of California, Los Angeles, CA, USA.
Ryan ChanDepartment of Medicine, Division of NanoMedicine, University of California, Los Angeles, CA, USA.
Huan MengDepartment of Medicine, Division of NanoMedicine, University of California, Los Angeles, CA, USA.
University of California, Los Angeles · USCalifornia NanoSystems Institute · US

Funding

UCLA Multifunctional Mesoporous Silica Nanoparticle Platform for Treatment of Pancreas CancerU01CA198846 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DONAHUE, TIMOTHY R, MENG, HUAN · 2015 to 2019
$2.4M
NCI NIH HHS U01 CA198846
6 · The paper itself

Abstract

Many solid tumor types, such as pancreatic cancer, have a generally poor prognosis, in part because the delivery of therapeutic regimen is prohibited by pathological abnormalities that block access to tumor vasculature, leading to poor bioavailability. Recent development of tumor penetrating iRGD peptide that is covalently conjugated on nanocarriers' surface or co-administered with nanocarriers becomes a popular approach for tumor targeting. More importantly, scientists have unlocked an important tumor transcytosis mechanism by which drug carrying nanoparticles directly access solid tumors (without the need of leaky vasculature), thereby allowing systemically injected nanocarriers more abundantly distribute at tumor site with improved efficacy. In this focused review, we summarized the design and implementation strategy for iRGD-mediated tumor targeting. This includes the working principle of such peptide and discussion on patient-specific iRGD effect in vivo, commensurate with the level of key biomarker (i.e. neuropilin-1) expression on tumor vasculature. This highlights the necessity to contemplate the use of a personalized approach when iRGD technology is used in clinic.

Identifiers

PMID30498580
PMCPMC6258069
OpenAlexW2749323330

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.