Evidence map›Paper›PMID 30498568›Full record

ArticleF1000Research2018

The inhibition of checkpoint activation by telomeres does not involve exclusion of dimethylation of histone H4 lysine 20 (H4K20me2).

Julien Audry, Jinyu Wang, Jessica R Eisenstatt, Kathleen L Berkner, Kurt W Runge

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in F1000Research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Julien AudryDepartment of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Lerner College of Medicine, Case Western Reserve University, Cleveland, OH, 44195, USA.
Jinyu WangDepartment of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Lerner College of Medicine, Case Western Reserve University, Cleveland, OH, 44195, USA.
Jessica R EisenstattDepartment of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Lerner College of Medicine, Case Western Reserve University, Cleveland, OH, 44195, USA.
Kathleen L BerknerDepartment of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Lerner College of Medicine, Case Western Reserve University, Cleveland, OH, 44195, USA.
Kurt W RungeDepartment of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Lerner College of Medicine, Case Western Reserve University, Cleveland, OH, 44195, USA.ORCID 0000-0001-8492-0530
Cleveland Clinic Lerner College of Medicine · US

Funding

CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024989 · NCRR · CASE WESTERN RESERVE UNIVERSITY · PI DAVIS, PAMELA B · 2007 to 2011
$53.7M
STRUCTURE/FUNCTION ANALYSIS OF THE GAMMA-CARBOXYLASER01HL055666 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI BERKNER, KATHLEEN LUCILE · 1997 to 2017
$5.4M
Vitamin K Oxidoreductase: Function and PhysiologyR01HL081093 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI BERKNER, KATHLEEN LUCILE · 2008 to 2017
$3.4M
REGULATION OF TELOMERE LENGTHR01GM050752 · NIGMS · CLEVELAND CLINIC LERNER COM-CWRU · PI RUNGE, KURT W · 1994 to 2012
$3.2M
Regulation of lifespanR01AG051601 · NIA · CLEVELAND CLINIC LERNER COM-CWRU · PI RUNGE, KURT W · 2016 to 2020
$1.6M
NHLBI NIH HHS R01 HL055666NHLBI NIH HHS R01 HL081093NIA NIH HHS R01 AG051601NIGMS NIH HHS R01 GM050752
6 · The paper itself

Abstract

DNA double-strand breaks (DSBs) activate the DNA damage checkpoint machinery to pause or halt the cell cycle.  Telomeres, the specific DNA-protein complexes at linear eukaryotic chromosome ends, are capped DSBs that do not activate DNA damage checkpoints.  This "checkpoint privileged" status of telomeres was previously investigated in the yeast

Indexed as

Cell Cycle CheckpointsHistonesSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSchizosaccharomycesSchizosaccharomyces pombe ProteinsTelomereDNA DamageMethylationHistonesSaccharomyces cerevisiae ProteinsSchizosaccharomyces pombe ProteinscheckpointDNA damageFission yeastH4K20me2histonemethylationtelomere

Identifiers

PMID30498568
PMCPMC6240467
OpenAlexW2878844715

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.