Evidence map›Paper›PMID 30498432›Full record

ArticleFrontiers in molecular neuroscience2018

Long-Term Labeling of Hippocampal Neural Stem Cells by a Lentiviral Vector.

Hoonkyo Suh, Qi-Gang Zhou, Irene Fernandez-Carasa, Gregory Dane Clemenson, Meritxell Pons-Espinal, Eun Jeoung Ro, Mercè Marti, Angel Raya, Fred H Gage, Antonella Consiglio

Open access · goldAbstract read
In one paragraph

Article in Frontiers in molecular neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 3 countries.

Hoonkyo SuhDepartment of Neurosciences, Cleveland Clinic, Lerner Research Institute, Cleveland, OH, United States.
Qi-Gang ZhouDepartment of Neurosciences, Cleveland Clinic, Lerner Research Institute, Cleveland, OH, United States.
Irene Fernandez-CarasaDepartment of Pathology and Experimental Therapeutics, Institut d'Investigació Biomédica de Bellvitge, Bellvitge University Hospital, Barcelona, Spain.
Gregory Dane ClemensonGene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, United States.
Meritxell Pons-EspinalDepartment of Pathology and Experimental Therapeutics, Institut d'Investigació Biomédica de Bellvitge, Bellvitge University Hospital, Barcelona, Spain.
Eun Jeoung RoDepartment of Neurosciences, Cleveland Clinic, Lerner Research Institute, Cleveland, OH, United States.
Mercè MartiCenter of Regenerative Medicine in Barcelona, Hospital Duran i Reynals, Barcelona, Spain.
Angel RayaCenter of Regenerative Medicine in Barcelona, Hospital Duran i Reynals, Barcelona, Spain.
Fred H GageGene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, United States.
Antonella ConsiglioDepartment of Pathology and Experimental Therapeutics, Institut d'Investigació Biomédica de Bellvitge, Bellvitge University Hospital, Barcelona, Spain.
Cleveland Clinic Lerner College of Medicine · USInstitut d'Investigació Biomédica de Bellvitge · ESSalk Institute for Biological Studies · USBiomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine · ESInstitució Catalana de Recerca i Estudis Avançats · ESInstitut de Biomedicina de la Universitat de Barcelona

Funding

Alcohol-induced neurogenesisR01AA022377 · NIAAA · CLEVELAND CLINIC LERNER COM-CWRU · PI SUH, HOONKYO · 2014 to 2018
$1.8M
NIAAA NIH HHS R01 AA022377
6 · The paper itself

Abstract

Using a lentivirus-mediated labeling method, we investigated whether the adult hippocampus retains long-lasting, self-renewing neural stem cells (NSCs). We first showed that a single injection of a lentiviral vector expressing a green fluorescent protein (LV PGK-GFP) into the subgranular zone (SGZ) of the adult hippocampus enabled an efficient, robust, and long-term marking of self-renewing NSCs and their progeny. Interestingly, a subset of labeled cells showed the ability to proliferate multiple times and give rise to Sox2

Indexed as

hippocampal neurogenesislentiviral vectorslesionneural stem cellstargeting

Identifiers

PMID30498432
PMCPMC6249367
OpenAlexW2901261626

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.