ArticleFrontiers in neuroscience2018
Voxel-Based Statistical Analysis of 3D Immunostained Tissue Imaging.
Article in Frontiers in neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 9 citations in OpenAlex.
- Classification of female MDD patients with and without suicidal ideation using resting-state functional magnetic resonance imaging and machine learning.Frontiers in human neuroscience · 2024Article
- The mouse brain after foot shock in four dimensions: Temporal dynamics at a single-cell resolution.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Reduced and stable feature sets selection with random forest for neurons segmentation in histological images of macaque brain.Scientific reports · 2021Article
- Tissue Clearing and Expansion Methods for Imaging Brain Pathology in Neurodegeneration: From Circuits to Synapses and Beyond.Frontiers in neuroscience · 2020Review
- Automated Individualization of Size-Varying and Touching Neurons in Macaque Cerebral Microscopic Images.Frontiers in neuroanatomy · 2019Article
Corrections and comments
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Authors and funding
12 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recently developed techniques to visualize immunostained tissues in 3D and in large samples have expanded the scope of microscopic investigations at the level of the whole brain. Here, we propose to adapt voxel-based statistical analysis to 3D high-resolution images of the immunostained rodent brain. The proposed approach was first validated with a simulation dataset with known cluster locations. Then, it was applied to characterize the effect of ADAM30, a gene involved in the metabolism of the amyloid precursor protein, in a mouse model of Alzheimer's disease. This work introduces voxel-based analysis of 3D immunostained microscopic brain images and, therefore, opens the door to localized whole-brain exploratory investigation of pathological markers and cellular alterations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.