Evidence map›Paper›PMID 30498419›Full record

ReviewBreast care (Basel, Switzerland)2018

Lymph Nodes in Breast Cancer - What Can We Learn from Translational Research?

Florentia Peintinger, Roland Reitsamer, Marjolein L Smidt, Thorsten Kühn, Cornelia Liedtke

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Breast care (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 3 countries.

Florentia PeintingerInstitute of Pathology, Medical University Graz, Graz, Austria.
Roland ReitsamerDepartment of Senology, Paracelsus Medical University Salzburg, Salzburg, Austria.
Marjolein L SmidtDepartment of Surgical Oncology, Maastricht University Medical Centre, Maastricht, The Netherlands.
Thorsten KühnDepartment of Gynecology and Obstetrics, Hospital Esslingen, Esslingen, Germany.
Cornelia LiedtkeCharité-Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, Germany.
Charité - Universitätsmedizin Berlin · DEKlinikum Esslingen · DEMaastricht University Medical Centre · NLMedical University of Graz · ATParacelsus Medical University · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clinical observations about lack of survival benefit after extensive axillary surgery and biological discordance between primary breast tumors and axillary lymph nodes raise the question of the actual metastatic potential of axillary nodal disease. The exploration of intratumoral heterogeneity and detection of genomic differences between the primary and lymph nodes indicate some similarity between the number of mutations in synchronous axillary node metastases and those in the primary lesion, suggesting a favorable prognosis. The hematogenous route of metastasis needs to be considered in findings of different subclones between nodal and distant metastases. Modern tools such as whole-genome sequencing applied in multiple tumor areas may guide more precisely the extent of axillary surgery.

Indexed as

Breast cancerGenomicsLymph node

Identifiers

PMID30498419
PMCPMC6257149
OpenAlexW2892425123

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.