Evidence map›Paper›PMID 30498409›Full record

ReviewTransfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie2018

An International Registry of Granulocyte Transfusions.

Monica B Pagano, Suzy Morton, Claudia S Cohn, Sylvie Gross, Jose Kutner, Antoine Lewin, Jeffrey McCullough, Irwin Schweitzer, Alan T Tinmouth, Kamille West and 1 more

Open access · bronzeAbstract readReview
In one paragraph

Review in Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Granulocytapheresis Donor Deferrals Pattern at a Pediatric Tertiary Care Centre in Northern India.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2024
    Article
  4. Article
  5. Article
  6. Granulocytes: From Basic Research to Clinical Use.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2018
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 10 institutions in 5 countries.

Monica B PaganoLaboratory Medicine, University of Washington Medical Center, Seattle, WA, USA.
Suzy MortonNHS Blood and Transplant, University Hospitals Birmingham, Birmingham, UK.
Claudia S CohnLaboratory Medicine and Pathology, University of Minnesota Medical Center, Minneapolis, MN, USA.
Sylvie GrossEtablissement Français du Sang, La Plaine-Saint Denis, France.
Jose KutnerHemotherapy and Cell Therapy, Hospital Israelita Albert Einstein, Sao Paulo, Bazil.
Antoine LewinMedical Affairs and Innovation, Héma-Québec, Montreal, QC, Canada.
Jeffrey McCulloughLaboratory Medicine and Pathology, University of Minnesota Medical Center, Minneapolis, MN, USA.
Irwin SchweitzerClinical Epidemiology Program Center for Transfusion Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Alan T TinmouthDepartments of Medicine and Laboratory Medicine and Pathology, Ottawa Hospital Center for Transfusion Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Kamille WestDepartment of Transfusion Medicine, National Institutes of Health Clinical Center, Bethesda, MD, USA.
Simon J StanworthNHS Blood & Transplant/Oxford University Hospitals NHS Foundation Trust, and University of Oxford; Oxford, UK.
University of Minnesota Medical Center · USÉtablissement Français du Sang · FRHéma-Québec · CAHospital Israelita Albert Einstein · BRNational Institutes of Health Clinical Center · USNHS Blood and Transplant · GBOttawa Hospital · CAOttawa Hospital Research InstituteUniversity of Oxford · GBUniversity of Washington Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionGranulocyte transfusions are used to either treat or prevent life-threatening infections in neutropenic patients. Current evidence from clinical trials does not support or reject efficacy, nor guide practice.

methodsA group of investigators have led the efforts to create an online registry to gather information on granulocyte transfusion practices from as broad a range of international settings. The data forms were adapted from an on-going study in England for electronic data management. Data is collected at the time of the request for granulocytes, weekly, at 28 days, and at 6 months. Information collected includes donor, granulocyte unit, patient and illness characteristics, and outcomes.

resultsThe PROspective GRanulocyte usage and outcomEs Survey (ProGrES) is currently open for data entry. Centres across the UK have collected data on 80 subjects. Five institutions from 4 countries (2 from the US, 1 each from Brazil, and national services in Canada and France) are in the process of joining the study. Other countries have expressed interest.

conclusionIt is feasible to develop an international registry of granulocyte transfusions to characterise current practices and describe outcomes. This registry would provide a platform to explore the relationship between intervention and outcomes, and to generate evidence to inform granulocyte transfusion efficacy.

Indexed as

GranulocytesInfectionNeutropeniaRegistry

Identifiers

PMID30498409
PMCPMC6257207
OpenAlexW2888164692

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.