Evidence map›Paper›PMID 30498403›Full record

ArticleContrast media & molecular imaging2018

Manganese-Enhanced T

N B Spath, D M L Lilburn, G A Gray, L M Le Page, G Papanastasiou, R J Lennen, R L Janiczek, M R Dweck, D E Newby, P C Yang and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Contrast media & molecular imaging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Manganese-Enhanced Magnetic Resonance Imaging of the Heart.Journal of magnetic resonance imaging : JMRI · 2023
    Review
  6. Review
  7. Modelling [European journal of nuclear medicine and molecular imaging · 2021
    Article
  8. Article
  9. Quantification of Macrophage-Driven Inflammation During Myocardial Infarction withJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2021
    Article
  10. Review
  11. Progression and regression of left ventricular hypertrophy and myocardial fibrosis in a mouse model of hypertension and concomitant cardiomyopathy.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2020
    Article
  12. Manganese-enhanced TScientific reports · 2020
    Article
  13. Review
  14. New Strategies in the Design of Paramagnetic CAs.Contrast media & molecular imaging · 2020
    Review
  15. Manganese-enhanced MRI of the myocardium.Heart (British Cardiac Society) · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

N B SpathBritish Heart Foundation Centre of Cardiovascular Science, University of Edinburgh, Edinburgh, UK.ORCID 0000-0001-9623-0158
D M L LilburnCentre for Inflammation Research, University of Edinburgh, Edinburgh, UK.
G A GrayBritish Heart Foundation Centre of Cardiovascular Science, University of Edinburgh, Edinburgh, UK.
L M Le PageBritish Heart Foundation Centre of Cardiovascular Science, University of Edinburgh, Edinburgh, UK.
G PapanastasiouBritish Heart Foundation Centre of Cardiovascular Science, University of Edinburgh, Edinburgh, UK.
R J LennenBritish Heart Foundation Centre of Cardiovascular Science, University of Edinburgh, Edinburgh, UK.
R L JaniczekGlaxoSmithKline, Gunnels Wood Road, Stevenage, Hertfordshire, UK.
M R DweckBritish Heart Foundation Centre of Cardiovascular Science, University of Edinburgh, Edinburgh, UK.
D E NewbyBritish Heart Foundation Centre of Cardiovascular Science, University of Edinburgh, Edinburgh, UK.
P C YangDepartment of Cardiology, Stanford University, Stanford, CA, USA.ORCID 0000-0002-6274-895X
M A JansenBritish Heart Foundation Centre of Cardiovascular Science, University of Edinburgh, Edinburgh, UK.
S I SempleBritish Heart Foundation Centre of Cardiovascular Science, University of Edinburgh, Edinburgh, UK.
British Heart Foundation · GBEdinburgh Royal Infirmary · GBCentre for Inflammation Research · GBGlaxoSmithKline (United Kingdom) · GBStanford University · US

Funding

Patient Oriented Research in Cardiovascular RegenerationK24HL130553 · NHLBI · STANFORD UNIVERSITY · PI YANG, PHILLIP CHUNG-MING · 2016 to 2020
$584k
British Heart Foundation CH/09/002British Heart Foundation FS/17/19/32641British Heart Foundation RE/13/3/30183British Heart Foundation RG/14/3/30706British Heart Foundation RG/16/10/32375British Heart Foundation RM/13/2/30158Medical Research Council G0701127NHLBI NIH HHS K24 HL130553Wellcome TrustWellcome Trust WT103782AIA
6 · The paper itself

Abstract

Background: Manganese-enhanced MRI (MEMRI) has the potential to identify viable myocardium and quantify calcium influx and handling. Two distinct manganese contrast media have been developed for clinical application, mangafodipir and EVP1001-1, employing different strategies to mitigate against adverse effects resulting from calcium-channel agonism. Mangafodipir delivers manganese ions as a chelate, and EVP1001-1 coadministers calcium gluconate. Using myocardial T Methods: T Results: Both manganese agents induced concentration-dependent shortening of myocardial T Conclusions: MEMRI causes concentration and calcium channel-dependent myocardial T

Indexed as

Coronary VesselsMagnetic Resonance ImagingMyocardial InfarctionAnimalsContrast MediaMaleManganeseMyocardiumRatsRats, Sprague-DawleyContrast MediaEVP 1001-1Manganese

Identifiers

PMID30498403
PMCPMC6222240
OpenAlexW2898165088

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.