Evidence map›Paper›PMID 30498397›Full record

ArticleCancer cell international2018

Biological indicators of chemoresistance: an ex vivo analysis of γH2AX and

Yike Bing, Zacharie Wund, Tina Abratte, Lucia Borlle, Susie Kang, Teresa Southard, Kelly R Hume

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer cell international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yike Bing1Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY USA.
Zacharie Wund1Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY USA.
Tina Abratte1Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY USA.
Lucia Borlle1Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY USA.
Susie Kang1Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY USA.
Teresa Southard2Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY USA.
Kelly R Hume1Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY USA.ORCID 0000-0001-9935-2118
Cornell University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe response of soft tissue sarcomas to cytotoxic chemotherapy is inconsistent. Biomarkers of chemoresistance or chemosensitivity are needed in order to identify appropriate patients for treatment. Given that many chemotherapeutics kill cells through direct DNA interactions, we hypothesized that upregulation of DNA damage response mechanisms would confer resistance to cytotoxic chemotherapy in sarcomas. To study this, we used spontaneously-occurring feline injection-site sarcomas (FISS).

methodsγH2AX and

resultsAn association was detected between γH2AX expression and relative survival in cells exposed to carboplatin (

conclusionsγH2AX expression, but not wild type

Indexed as

Animal modelChemoresistanceDNA damageGammaH2AXSarcoma

Identifiers

PMID30498397
PMCPMC6251226
OpenAlexW2901140366

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.