Evidence map›Paper›PMID 30498366›Full record

ArticleInfection and drug resistance2018

The biological evaluation of fusidic acid and its hydrogenation derivative as antimicrobial and anti-inflammatory agents.

Pan-Pan Wu, Hao He, W David Hong, Tong-Rong Wu, Gui-Ying Huang, Ying-Ying Zhong, Bo-Rong Tu, Min Gao, Jun Zhou, Su-Qing Zhao and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and drug resistance, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. An overview on natural farnesyltransferase inhibitors for efficient cancer therapy.Journal of enzyme inhibition and medicinal chemistry · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 2 countries.

Pan-Pan WuFaculty of Chemical and Environmental Engineering, Wuyi University, Jiangmen, China, sqzhao@gdut.edu.cn; kzhang@gdut.edu.cn.
Hao HeFaculty of Chemical and Environmental Engineering, Wuyi University, Jiangmen, China, sqzhao@gdut.edu.cn; kzhang@gdut.edu.cn.
W David HongFaculty of Chemical and Environmental Engineering, Wuyi University, Jiangmen, China, sqzhao@gdut.edu.cn; kzhang@gdut.edu.cn.
Tong-Rong WuFaculty of Chemical and Environmental Engineering, Wuyi University, Jiangmen, China, sqzhao@gdut.edu.cn; kzhang@gdut.edu.cn.
Gui-Ying HuangDepartment of Pharmaceutical Engineering, Faculty of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou, China, sqzhao@gdut.edu.cn; kzhang@gdut.edu.cn.
Ying-Ying ZhongDepartment of Pharmaceutical Engineering, Faculty of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou, China, sqzhao@gdut.edu.cn; kzhang@gdut.edu.cn.
Bo-Rong TuFaculty of Chemical and Environmental Engineering, Wuyi University, Jiangmen, China, sqzhao@gdut.edu.cn; kzhang@gdut.edu.cn.
Min GaoFaculty of Chemical and Environmental Engineering, Wuyi University, Jiangmen, China, sqzhao@gdut.edu.cn; kzhang@gdut.edu.cn.
Jun ZhouFaculty of Chemical and Environmental Engineering, Wuyi University, Jiangmen, China, sqzhao@gdut.edu.cn; kzhang@gdut.edu.cn.
Su-Qing ZhaoFaculty of Chemical and Environmental Engineering, Wuyi University, Jiangmen, China, sqzhao@gdut.edu.cn; kzhang@gdut.edu.cn.
Dong-Li LiFaculty of Chemical and Environmental Engineering, Wuyi University, Jiangmen, China, sqzhao@gdut.edu.cn; kzhang@gdut.edu.cn.
Xue-Tao XuFaculty of Chemical and Environmental Engineering, Wuyi University, Jiangmen, China, sqzhao@gdut.edu.cn; kzhang@gdut.edu.cn.
Zhao-Jun ShengFaculty of Chemical and Environmental Engineering, Wuyi University, Jiangmen, China, sqzhao@gdut.edu.cn; kzhang@gdut.edu.cn.
Stephen A WardResearch Centre for Drugs and Diagnostics, Liverpool School of Tropical Medicine, Liverpool, UK.
Paul M O'NeillDepartment of Chemistry, University of Liverpool, UK.
Kun ZhangFaculty of Chemical and Environmental Engineering, Wuyi University, Jiangmen, China, sqzhao@gdut.edu.cn; kzhang@gdut.edu.cn.
Wuyi University · CNGuangdong University of Technology · CNLiverpool School of Tropical Medicine · GBUniversity of Liverpool · GB

Funding

Medical Research Council MC_PC_17167
6 · The paper itself

Abstract

backgroundFusidic acid (FA) (WU-FA-00) is the only commercially available antimicrobial from the fusidane family that has a narrow spectrum of activity against Gram-positive bacteria.

methodsHerein, the hydrogenation derivative (WU-FA-01) of FA was prepared and both compounds were examined against a panel of six bacterial strains. In addition, their anti-inflammatory properties were evaluated using a 12-

resultsThe results of the antimicrobial assay revealed that both WU-FA-00 and WU-FA-01 displayed a high level of antimicrobial activity against Gram-positive strains. Moreover, killing kinetic studies were performed and the results were in accordance with the minimum inhibitory concentration and minimum bactericidal concentration results. We also demonstrated that the topical application of WU-FA-00 and WU-FA-01 effectively decreased TPA-induced ear edema in a dose-dependent manner. This inhibitory effect was associated with the inhibition of TPA-induced upregulation of proinflammatory cytokines IL-1β, TNF-α, and COX-2. WU-FA-01 significantly suppressed the expression levels of p65, IκB-α, and p-IκB-α in the TPA-induced mouse ear model.

conclusionOverall, our results showed that WU-FA-00 and WU-FA-01 not only had effective antimicrobial activities in vitro, especially to the Gram-positive bacteria, but also possessed strong anti-inflammatory effects in vivo. These results provide a scientific basis for developing FA derivatives as antimicrobial and anti-inflammatory agents.

Indexed as

anti-inflammatoryantimicrobialderivativefusidic acid

Identifiers

PMID30498366
PMCPMC6207271
OpenAlexW2799087954

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.