Evidence map›Paper›PMID 30498344›Full record

ArticleInternational journal of nanomedicine2018

Plasma membrane is the target of rapid antibacterial action of silver nanoparticles in

Olesja M Bondarenko, Mariliis Sihtmäe, Julia Kuzmičiova, Lina Ragelienė, Anne Kahru, Rimantas Daugelavičius

Open access · goldAbstract read
In one paragraph

Article in International journal of nanomedicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 123 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Bioinspired Ag/CeOScientific reports · 2026
    Article
  6. Article
  7. Review
  8. Article
  9. AqueousNanomaterials (Basel, Switzerland) · 2025
    Article
  10. Article
  11. Sustainable, scalable nanotechnology approach using filtrate fromFrontiers in cellular and infection microbiology · 2025
    Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Silver Compounds for Caries Management.International dental journal · 2024
    Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Olesja M BondarenkoLaboratory of Environmental Toxicology, National Institute of Chemical Physics and Biophysics, Tallinn 12618, Estonia, olesja.bondarenko@kbfi.ee.
Mariliis SihtmäeLaboratory of Environmental Toxicology, National Institute of Chemical Physics and Biophysics, Tallinn 12618, Estonia, olesja.bondarenko@kbfi.ee.
Julia KuzmičiovaDepartment of Biochemistry, Vytautas Magnus University, Kaunas LT-44404, Lithuania.
Lina RagelienėDepartment of Biochemistry, Vytautas Magnus University, Kaunas LT-44404, Lithuania.
Anne KahruLaboratory of Environmental Toxicology, National Institute of Chemical Physics and Biophysics, Tallinn 12618, Estonia, olesja.bondarenko@kbfi.ee.
Rimantas DaugelavičiusDepartment of Biochemistry, Vytautas Magnus University, Kaunas LT-44404, Lithuania.
Vytautas Magnus University · LTNational Institute of Chemical Physics and Biophysics · EEEstonian Academy of Sciences · EE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSilver nanoparticles (AgNP) are widely used in consumer products and in medicine, mostly due to their excellent antimicrobial properties. One of the generally accepted antibacterial mechanisms of AgNP is their efficient contact with cells and dissolution in the close vicinity of bacterial cell envelope. Yet, the primary mechanism of cell wall damage and the events essential for bactericidal action of AgNP are not elucidated. MATERIALS AND

methodsIn this study we used a combination of various assays to differentiate the adverse effects of AgNP on bacterial cell envelope: outer membrane (OM) and plasma membrane (PM).

resultsWe showed that PM was the main target of AgNP in gram-negative bacteria

conclusionAgNP exhibited antibacterial properties via rapid release of Ag

Indexed as

Anti-Bacterial AgentsCell MembraneCell Membrane PermeabilityEscherichia coliMetal NanoparticlesPseudomonas aeruginosaSilverAnti-Bacterial AgentsSilverantimicrobialsbioluminescencecollargolgram-negativeinner membranemechanism of toxicitynanomaterialsouter membrane

Identifiers

PMID30498344
PMCPMC6207270
OpenAlexW2898556923

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.