Evidence map›Paper›PMID 30498258›Full record

ReviewNature reviews. Rheumatology2019

Intra-articular treatment options for knee osteoarthritis.

Ian A Jones, Ryan Togashi, Melissa L Wilson, Nathanael Heckmann, C Thomas Vangsness

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nature reviews. Rheumatology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03825133 (The Comparison of Knee Osteoarthritis Treatment With Single-dose of Bone Marrow Aspirate Concentrate, Single-dose of Leukocyte Rich Platelet Rich Plasma and 3 Injection of High Molecular Weight Hyaluronic Acid-A Randomized Clinical Trial), which is not on this map. Cited by 275 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
275citing papers in PubMed, 7 pooled it
28.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03825133 phase4completednot on this map

The Comparison of Knee Osteoarthritis Treatment With Single-dose of Bone Marrow Aspirate Concentrate, Single-dose of Leukocyte Rich Platelet Rich Plasma and 3 Injection of High Molecular Weight Hyaluronic Acid-A Randomized Clinical Trial

TypeinterventionalSponsorClinical Center of VojvodinaRan2016 to 2017Enrolled180ConditionsKnee OsteoarthritisArmsBone Marrow Aspirate Concentrate, Leukocyte Rich Platelet Rich Plasma, Hyaluronic Acid
3 · Its place in the literature

Who cites it

275 citing papers in PubMed, 7 syntheses or guidelines pooled it, 505 citations in OpenAlex.

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215 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Ian A JonesDepartment of Orthopaedic Surgery, Keck School of Medicine of USC, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-6051-4762
Ryan TogashiDepartment of Orthopaedic Surgery, Keck School of Medicine of USC, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0001-5481-9925
Melissa L WilsonDepartment of Preventive Medicine, Keck School of Medicine of USC, Los Angeles, CA, USA.
Nathanael HeckmannDepartment of Orthopaedic Surgery, Keck School of Medicine of USC, Los Angeles, CA, USA.
C Thomas VangsnessDepartment of Orthopaedic Surgery, Keck School of Medicine of USC, Los Angeles, CA, USA. vangsness@usc.edu.ORCID http://orcid.org/0000-0002-0143-0155
Keck Hospital of USC · US

Funding

Southern California Clinical and Translational Science InstituteUL1TR001855 · NCATS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Thomas A Buchanan, Michele D. Kipke · 2016 to 2026
$81.3M
Southern California Clinical and Translational Science InstituteUL1TR000130 · NCATS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BUCHANAN, THOMAS A · 2012 to 2015
$36.0M
NCATS NIH HHS UL1 TR000130NCATS NIH HHS UL1 TR001855
6 · The paper itself

Abstract

Intra-articular drug delivery has a number of advantages over systemic administration; however, for the past 20 years, intra-articular treatment options for the management of knee osteoarthritis (OA) have been limited to analgesics, glucocorticoids, hyaluronic acid (HA) and a small number of unproven alternative therapies. Although HA and glucocorticoids can provide clinically meaningful benefits to an appreciable number of patients, emerging evidence indicates that the apparent effectiveness of these treatments is largely a result of other factors, including the placebo effect. Biologic drugs that target inflammatory processes are used to manage rheumatoid arthritis, but have not translated well into use in OA. A lack of high-level evidence and methodological limitations hinder our understanding of so-called 'stem' cell therapies and, although the off-label administration of intra-articular cell therapies (such as platelet-rich plasma and bone marrow aspirate concentrate) is common, high-quality clinical data are needed before these treatments can be recommended. A number of promising intra-articular treatments are currently in clinical development in the United States, including small-molecule and biologic therapies, devices and gene therapies. Although the prospect of new, non-surgical treatments for OA is exciting, the benefits of new treatments must be carefully weighed against their costs and potential risks.

Indexed as

Cell- and Tissue-Based TherapyBiological FactorsDrug DevelopmentHumansInjections, Intra-ArticularOsteoarthritis, KneeBiological Factors

Identifiers

PMID30498258
PMCPMC6390843
OpenAlexW2902807504

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.