Evidence map›Paper›PMID 30498219›Full record

ArticleNature communications2018

Olfactory marker protein (OMP) regulates formation and refinement of the olfactory glomerular map.

Dinu F Albeanu, Allison C Provost, Prateek Agarwal, Edward R Soucy, Joseph D Zak, Venkatesh N Murthy

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 64 citations in OpenAlex.

  1. Article
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  7. Amplification of Olfactory Transduction Currents Implements Sparse Stimulus Encoding.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  8. Article
  9. Article
  10. The Accessory Olfactory Bulb inAnimals : an open access journal from MDPI · 2024
    Article
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  13. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Dinu F AlbeanuCold Spring Harbor Laboratory, Cold Spring Harbor, Cold Spring Harbor, NY, 11724, USA.
Allison C ProvostDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, MA, 02138, USA.
Prateek AgarwalDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, MA, 02138, USA.
Edward R SoucyDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, MA, 02138, USA.
Joseph D ZakDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, MA, 02138, USA.ORCID http://orcid.org/0000-0002-3148-5325
Venkatesh N MurthyDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, MA, 02138, USA. vnmurthy@fas.harvard.edu.ORCID http://orcid.org/0000-0003-2443-4252
Harvard University · USCold Spring Harbor Laboratory · US

Funding

Optogenetic studies of mouse olfactionR01DC011291 · NIDCD · HARVARD UNIVERSITY · PI MURTHY, VENKATESH N · 2011 to 2015
$1.7M
Information Coding in Individual Olfactory Sensory AxonsF32DC015938 · NIDCD · HARVARD UNIVERSITY · PI ZAK, JOSEPH DONALD · 2017 to 2019
$165k
NIDCD NIH HHS F32 DC015938NIDCD NIH HHS R01 DC011291
6 · The paper itself

Abstract

Inputs from olfactory sensory neuron (OSN) axons expressing the same type of odorant receptor (OR) converge in the glomerulus of the main olfactory bulb. A key marker of mature OSNs is olfactory marker protein (OMP), whose deletion has been associated with deficits in OSN signal transduction and odor discrimination. Here, we investigate glomerular odor responses and anatomical architecture in mice in which one or both alleles of OMP are replaced by the fluorescent synaptic activity reporter, synaptopHluorin. Functionally heterogeneous glomeruli, that is, ones with microdomains with distinct odor responses, are rare in OMP

Indexed as

AllelesAnimalsGenetic HeterogeneityImmunohistochemistryMiceMice, KnockoutMice, Mutant StrainsOlfactory BulbOlfactory Marker ProteinOlfactory Receptor NeuronsReceptors, OdorantOlfactory Marker ProteinReceptors, Odorant

Identifiers

PMID30498219
PMCPMC6265328
OpenAlexW2901700104

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.