ArticleEmerging microbes & infections2018
Altered gut microbiota after traumatic splenectomy is associated with endotoxemia.
Article in Emerging microbes & infections, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- Splenectomy and risk of hepatocellular carcinoma.World journal of hepatology · 2025Review
- Characteristics of Intestinal Flora in Patients With Schistosoma japonicum Infection Undergoing Splenectomy.Parasite immunology · 2025Article
- The microbiota-gut-brain axis in Huntington's disease: pathogenic mechanisms and therapeutic targets.The FEBS journal · 2025Review
- Supplementing Ryegrass Ameliorates Commercial Diet-Induced Gut Microbial Dysbiosis-Associated Spleen Dysfunctions by Gut-Microbiota-Spleen Axis.Nutrients · 2024Article
- Splenectomy ameliorates liver cirrhosis by restoring the gut microbiota balance.Cellular and molecular life sciences : CMLS · 2024Article
- Investigating gut microbiota-blood and urine metabolite correlations in early sepsis-induced acute kidney injury: insights from targeted KEGG analyses.Frontiers in cellular and infection microbiology · 2024Observational
- Effect of antimicrobial administration on fecal microbiota of critically ill dogs: dynamics of antimicrobial resistance over time.Animal microbiome · 2022Article
- The gut microbiome contributes to splenomegaly and tissue inflammation in a murine model of primary biliary cholangitis.Annals of translational medicine · 2022Article
- Enhanced Bacteremia in Dextran Sulfate-Induced Colitis in Splenectomy Mice Correlates with Gut Dysbiosis and LPS Tolerance.International journal of molecular sciences · 2022Article
- Contribution of gut microbiota toward renal function in sepsis.Frontiers in microbiology · 2022Review
- Abnormalities of the composition of the gut microbiota and short-chain fatty acids in mice after splenectomy.Brain, behavior, & immunity - health · 2021Article
- Methyl Diet Enhanced Sepsis-Induced Mortality Through Altering Gut Microbiota.Journal of inflammation research · 2021Article
- Low-Abundant Microorganisms: The Human Microbiome's Dark Matter, a Scoping Review.Frontiers in cellular and infection microbiology · 2021Article
- Preoperative Microbiomes and Intestinal Barrier Function Can Differentiate Prodromal Alzheimer's Disease From Normal Neurocognition in Elderly Patients Scheduled to Undergo Orthopedic Surgery.Frontiers in cellular and infection microbiology · 2021Article
- Astaxanthin Alleviates Ochratoxin A-Induced Cecum Injury and Inflammation in Mice by Regulating the Diversity of Cecal Microbiota and TLR4/MyD88/NF-Oxidative medicine and cellular longevity · 2021Article
- Therapeutic Potential of the Gut Microbiota in the Management of Sepsis.Critical care (London, England) · 2020Review
- Article
- Lack of Gut Secretory Immunoglobulin A in Memory B-Cell Dysfunction-Associated Disorders: A Possible Gut-Spleen Axis.Frontiers in immunology · 2019Article
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Authors and funding
9 authors at 2 institutions in 1 country.
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Abstract
Splenectomy carries a long-term risk of postoperative infection, and the chronic, low-grade inflammation associated with endotoxemia may be related to the gut microbiota. In this study, to increase our understanding of the potential cause of the high rate of infection in postsplenectomy patients, we evaluated the differences in the gut microbiota and plasma lipopolysaccharide level of patients after splenectomy relative to those of healthy controls. Thirty-two patients having undergone splenectomy and 42 healthy individuals were enrolled into the splenectomy (SP) and healthy control (HC) groups, respectively. The SP group was subdivided into three subgroups according to the length of their postoperative time. Fecal samples were used for gut microbiota analysis via 16s rRNA gene sequencing, blood examinations and plasma lipopolysaccharide measurements were also taken. Significant differences were observed in gut microbiota composition with regard to the relative bacterial abundances of 2 phyla, 7 families, and 15 genera. The lipopolysaccharide level was significantly higher in the SP group than in the HC group and were negatively associated with five bacterial families with low abundance in the SP group. The degree of the microbiota alteration increased with the length of the postoperative time. The PICRUSt analysis showed that the relative abundances of lipopolysaccharide biosynthesis proteins and lipopolysaccharide biosynthesis pathways were higher in the SP group and were positively associated with the plasma lipopolysaccharide level. Significant alterations were observed in the gut microbiota of the splenectomized patients and were associated with plasma lipopolysaccharide level. Further studies are needed to verify whether such alterations after splenectomy are related to an increased risk of complications.
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