Evidence map›Paper›PMID 30498131›Full record

ArticleThe EMBO journal2019

Precocious expression of Blimp1 in B cells causes autoimmune disease with increased self-reactive plasma cells.

Peter Bönelt, Miriam Wöhner, Martina Minnich, Hiromi Tagoh, Maria Fischer, Markus Jaritz, Anoop Kavirayani, Manasa Garimella, Mikael Ci Karlsson, Meinrad Busslinger

Open access · hybridAbstract read
In one paragraph

Article in The EMBO journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Specific hypomethylation programs underpin B cell activation in early multiple sclerosis.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  10. Article
  11. An in vivo screen of noncoding loci reveals thatProceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Peter BöneltResearch Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Vienna, Austria.
Miriam WöhnerResearch Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Vienna, Austria.
Martina MinnichResearch Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Vienna, Austria.
Hiromi TagohResearch Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Vienna, Austria.
Maria FischerResearch Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Vienna, Austria.
Markus JaritzResearch Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Vienna, Austria.
Anoop KavirayaniVienna Biocenter Core Facilities (VBCF), Vienna Biocenter (VBC), Vienna, Austria.
Manasa GarimellaDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
Mikael Ci KarlssonDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
Meinrad BusslingerResearch Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Vienna, Austria busslinger@imp.ac.at.ORCID 0000-0002-9111-9351
Research Institute of Molecular Pathology · ATKarolinska Institutet · SEVienna Biocenter · AT

Funding

European Research Council 291740
6 · The paper itself

Abstract

The transcription factor Blimp1 is not only an essential regulator of plasma cells, but also a risk factor for the development of autoimmune disease in humans. Here, we demonstrate in the mouse that the

Indexed as

AnimalsAutoantibodiesB-LymphocytesCell DifferentiationDisease Models, AnimalFemaleGene Regulatory NetworksGlomerulonephritisHumansMaleMicePositive Regulatory Domain I-Binding Factor 1Transcriptional ActivationAutoantibodiesPositive Regulatory Domain I-Binding Factor 1Prdm1 protein, mouseautoimmune diseaseBlimp1‐mediated loss of B cellsectopic expression throughout the B cell lineageincreased plasma cells differentiationPrdm1 (Blimp1) transcription in developing B cells

Identifiers

PMID30498131
PMCPMC6331720
OpenAlexW2902655558

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.