Evidence map›Paper›PMID 30498130›Full record

ArticleThe EMBO journal2019

A pathogenic role for cystic fibrosis transmembrane conductance regulator in celiac disease.

Valeria R Villella, Andrea Venerando, Giorgio Cozza, Speranza Esposito, Eleonora Ferrari, Romina Monzani, Mara C Spinella, Vasilis Oikonomou, Giorgia Renga, Antonella Tosco and 12 more

Open access · hybridAbstract read
In one paragraph

Article in The EMBO journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 58 citations in OpenAlex.

  1. Review
  2. Review
  3. Gastrointestinal tract, its pathophysiology andWorld journal of gastroenterology · 2025
    Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Autophagy in major human diseases.The EMBO journal · 2021
    Review
  15. Does cystic fibrosis make susceptible to celiac disease?European journal of pediatrics · 2021
    Article
  16. Article
  17. Article
  18. Article
  19. Structural Perspective of Gliadin Peptides Active in Celiac Disease.International journal of molecular sciences · 2020
    Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors at 11 institutions in 6 countries.

Valeria R VillellaEuropean Institute for Research in Cystic Fibrosis, San Raffaele Scientific Institute, Milan, Italy.
Andrea VenerandoDepartment of Comparative Biomedicine and Food Science, University of Padova, Padova, Italy.ORCID 0000-0003-0379-2309
Giorgio CozzaDepartment of Molecular Medicine, University of Padova, Padova, Italy.
Speranza EspositoEuropean Institute for Research in Cystic Fibrosis, San Raffaele Scientific Institute, Milan, Italy.
Eleonora FerrariEuropean Institute for Research in Cystic Fibrosis, San Raffaele Scientific Institute, Milan, Italy.
Romina MonzaniEuropean Institute for Research in Cystic Fibrosis, San Raffaele Scientific Institute, Milan, Italy.
Mara C SpinellaEuropean Institute for Research in Cystic Fibrosis, San Raffaele Scientific Institute, Milan, Italy.
Vasilis OikonomouDepartment of Experimental Medicine, University of Perugia, Perugia, Italy.
Giorgia RengaDepartment of Experimental Medicine, University of Perugia, Perugia, Italy.
Antonella ToscoPediatric Unit, Department of Translational Medical Sciences, Regional Cystic Fibrosis Center, Federico II University Naples, Naples, Italy.
Federica RossinDepartment of Biology, University of Rome "Tor Vergata", Rome, Italy.
Stefano GuidoDepartment of Chemical, Materials and Production Engineering, Federico II University Naples, Naples, Italy.
Marco SilanoDepartment of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità, Roma, Italy.
Enrico GaraciUniversity San Raffaele and 21 IRCCS San Raffaele, Rome, Italy.
Yu-Kai ChaoDepartment of Pharmacology and Toxicology, Faculty of Medicine, University of Munich (LMU), Munich, Germany.ORCID 0000-0002-1202-2448
Christian GrimmDepartment of Pharmacology and Toxicology, Faculty of Medicine, University of Munich (LMU), Munich, Germany.
Alessandro LucianiInstitute of Physiology CH, University of Zurich, Zurich, Switzerland.
Luigina RomaniDepartment of Health Sciences, University of Eastern Piedmont, Novara, Italy.
Mauro PiacentiniDepartment of Biology, University of Rome "Tor Vergata", Rome, Italy.ORCID 0000-0003-2919-1296
Valeria RaiaPediatric Unit, Department of Translational Medical Sciences, Regional Cystic Fibrosis Center, Federico II University Naples, Naples, Italy.
Guido KroemerCentre de Recherche des Cordeliers, Equipe11 labellisée Ligue Nationale Contrele Cancer, Paris, France kroemer@orange.fr luigi.maiuri@gmail.com.ORCID 0000-0002-9334-4405
Luigi MaiuriEuropean Institute for Research in Cystic Fibrosis, San Raffaele Scientific Institute, Milan, Italy kroemer@orange.fr luigi.maiuri@gmail.com.ORCID 0000-0002-4962-9016
Università degli Studi del Piemonte Orientale “Amedeo Avogadro” · ITFederico II University Hospital · ITLudwig-Maximilians-Universität München · DEUniversity of Padua · ITUniversity of Perugia · ITUniversity of Rome Tor Vergata · ITDélégation Paris 5 · FRIstituto Superiore di Sanità · ITSan Raffaele University of Rome · ITUniversity of Naples Federico II · ITUniversity of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intestinal handling of dietary proteins usually prevents local inflammatory and immune responses and promotes oral tolerance. However, in ~ 1% of the world population, gluten proteins from wheat and related cereals trigger an HLA DQ2/8-restricted T

Indexed as

AdolescentAminophenolsAnimalsCaco-2 CellsCeliac DiseaseCell LineChildCystic Fibrosis Transmembrane Conductance RegulatorDisease Models, AnimalDown-RegulationFemaleGliadinHumansMaleMicePeptide FragmentsAminophenolsCFTR protein, humanCystic Fibrosis Transmembrane Conductance RegulatorGliadingliadin peptide (31-43)ivacaftorPeptide FragmentsQuinolonesceliac diseaseCFTRgliadinmucosal immunologyP31–43 peptide

Identifiers

PMID30498130
PMCPMC6331719
OpenAlexW2902606683

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.