Evidence map›Paper›PMID 30498088›Full record

ArticleThe Journal of biological chemistry2019

Mitochondrial ATP production provides long-range control of endothelial inositol trisphosphate-evoked calcium signaling.

Calum Wilson, Matthew D Lee, Helen R Heathcote, Xun Zhang, Charlotte Buckley, John M Girkin, Christopher D Saunter, John G McCarron

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 45 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Impact of aging on vascular ion channels: perspectives and knowledge gaps across major organ systems.American journal of physiology. Heart and circulatory physiology · 2023
    Review
  7. The Molecular Heterogeneity of Store-Operated CaInternational journal of molecular sciences · 2023
    Review
  8. Article
  9. Article
  10. Article
  11. CoClBiomedicines · 2022
    Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Targeting Mitochondrial Dysfunction for Bipolar Disorder.Current topics in behavioral neurosciences · 2021
    Review
  17. Article
  18. Article
  19. Review
  20. Uric acid and hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Calum WilsonFrom the Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, SIPBS Building, 161 Cathedral Street, Glasgow G4 0RE, Scotland, United Kingdom and c.wilson@strath.ac.uk.
Matthew D LeeFrom the Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, SIPBS Building, 161 Cathedral Street, Glasgow G4 0RE, Scotland, United Kingdom and.
Helen R HeathcoteFrom the Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, SIPBS Building, 161 Cathedral Street, Glasgow G4 0RE, Scotland, United Kingdom and.
Xun ZhangFrom the Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, SIPBS Building, 161 Cathedral Street, Glasgow G4 0RE, Scotland, United Kingdom and.
Charlotte BuckleyFrom the Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, SIPBS Building, 161 Cathedral Street, Glasgow G4 0RE, Scotland, United Kingdom and.
John M Girkinthe Centre for Advanced Instrumentation, Biophysical Sciences Institute, Department of Physics, Durham University, South Road, Durham DH1 3LE, United Kingdom.
Christopher D Saunterthe Centre for Advanced Instrumentation, Biophysical Sciences Institute, Department of Physics, Durham University, South Road, Durham DH1 3LE, United Kingdom.
John G McCarronFrom the Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, SIPBS Building, 161 Cathedral Street, Glasgow G4 0RE, Scotland, United Kingdom and john.mccarron@strath.ac.uk.
University of Strathclyde · GBDurham University · GB

Funding

British Heart Foundation PG/16/54/32230British Heart Foundation PG/16/82/32439British Heart Foundation PG16/82/32439Wellcome Trust 202924/Z/16/ZWellcome Trust 204682/Z/16/Z
6 · The paper itself

Abstract

Endothelial cells are reported to be glycolytic and to minimally rely on mitochondria for ATP generation. Rather than providing energy, mitochondria in endothelial cells may act as signaling organelles that control cytosolic Ca

Indexed as

Adenosine TriphosphateAnimalsCalcium SignalingCytoplasmEndothelial CellsInositol PhosphatesMaleMitochondriaRatsRats, Sprague-DawleyReactive Oxygen SpeciesAdenosine TriphosphateInositol PhosphatesReactive Oxygen SpeciesATPCa2+ signalingcalcium imagingcell signalingendoplasmic reticulum (ER)endothelial cellendotheliumfluorescence imaginginositol 1,4,5-trisphosphate (IP3)inositol trisphosphatemesenteric arterymitochondriamyoendothelial junctionreactive oxygen species (ROS)

Identifiers

PMID30498088
PMCPMC6341391
OpenAlexW2902591574

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.