ArticleBMJ open2018
Antibiotic use in children with asthma: cohort study in UK and Dutch primary care databases.
Article in BMJ open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- Antibiotic treatment for non-specific upper respiratory tract infections and exacerbation risk in children with asthma: a target trial emulation study.American journal of epidemiology · 2026Article
- Extended antibiotic exposure and exacerbations, mortality, and healthcare costs in asthma.Scientific reports · 2025Article
- A study on viruses and bacteria with particular interest on Mycoplasma pneumoniae in children with exacerbation of asthma from a tertiary care hospital in Sri Lanka.Access microbiology · 2024Article
- Comparison of chest radiograph and lung ultrasound in children with acute respiratory failure.Journal of ultrasound · 2023Observational
- Current Approaches in the Multimodal Management of Asthma in Adolescents-From Pharmacology to Personalized Therapy.Biomedicines · 2023Review
- Article
- Gut Microbiota in Nutrition and Health with a Special Focus on Specific Bacterial Clusters.Cells · 2022Review
- Impact of COVID-19 on primary care contacts with children and young people in England: longitudinal trends study 2015-2020.The British journal of general practice : the journal of the Royal College of General Practitioners · 2022Article
- Analysis of the Consumption of Drugs Prescribed for the Treatment of Asthma in Belgian Children.International journal of environmental research and public health · 2022Article
- Economic burden of peanut allergy in pediatric patients with evidence of reactions to peanuts in the United States.Journal of managed care & specialty pharmacy · 2021Article
- How many medications do doctors in primary care use? An observational study of the DU90% indicator in primary care in England.BMJ open · 2021Observational
- Tiotropium as an Add-on Treatment Option for Severe Uncontrolled Asthma in Preschool Patients.Journal of asthma and allergy · 2021Article
- Antibiotic use in children and youths with asthma: a population-based case-control study.ERJ open research · 2021Article
- First-Year Antibiotics Exposure in Relation to Childhood Asthma, Allergies, and Airway Illnesses.International journal of environmental research and public health · 2020Article
- Article
- Microbiology testing associated with antibiotic dispensing in older community-dwelling adults.BMC infectious diseases · 2020Article
- Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo compare the rate, indications and type of antibiotic prescriptions in children with and without asthma.
designA retrospective cohort study.
settingTwo population-based primary care databases: Integrated Primary Care Information database (IPCI; the Netherlands) and The Health Improvement Network (THIN; the UK).
participantsChildren aged 5-18 years were included from January 2000 to December 2014. A child was categorised as having asthma if there were ≥2 prescriptions of respiratory drugs in the year following a code for asthma. Children were labelled as non-asthmatic if no asthma code was recorded in the patient file.
main outcome measuresRate of antibiotic prescriptions, related indications and type of antibiotic drugs.
resultsThe cohorts in IPCI and THIN consisted of 946 143 and 7 241 271 person years (PY), respectively. In both cohorts, antibiotic use was significantly higher in asthmatic children (IPCI: 197vs126 users/1000 PY, THIN: 374vs250 users/1000 PY). In children with asthma, part of antibiotic prescriptions were for an asthma exacerbation only (IPCI: 14%, THIN: 4%) and prescriptions were more often due to lower respiratory tract infections then in non-asthmatic children (IPCI: 18%vs13%, THIN: 21%vs12%). Drug type and quality indicators depended more on age, gender and database than on asthma status.
conclusionsUse of antibiotics was higher in asthmatic children compared with non-asthmatic children. This was mostly due to diseases for which antibiotics are normally not indicated according to guidelines. Further awareness among physicians and patients is needed to minimise antibiotic overuse and limit antibiotic resistance.
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