Evidence map›Paper›PMID 30498038›Full record

ArticleBMJ open2018

Association of IL-10 and IL-10RA single nucleotide polymorphisms with the responsiveness to HBV vaccination in Chinese infants of HBsAg(+)/HBeAg(-) mothers: a nested case-control study.

Simin Wen, Yanhua Wu, Yuchen Pan, Mengzhuo Cao, Dan Zhao, Chong Wang, Chuan Wang, Fei Kong, Jie Li, Junqi Niu and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 80% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Simin Wen *Department of Clinical Research, First Hospital of Jilin University, Changchun, China.
Yanhua Wu *Department of Clinical Research, First Hospital of Jilin University, Changchun, China.
Yuchen PanDepartment of Clinical Research, First Hospital of Jilin University, Changchun, China.
Mengzhuo CaoDepartment of Microbiology and Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.
Dan ZhaoDepartment of Clinical Research, First Hospital of Jilin University, Changchun, China.
Chong WangDepartment of Hepatology, First Hospital of Jilin University, Changchun, China.
Chuan WangDepartment of Child Healthcare, Maternal and Child Health Care and Family Planning Service Center of Chaoyang District, Beijing, China.
Fei KongDepartment of Hepatology, First Hospital of Jilin University, Changchun, China.
Jie LiDepartment of Microbiology and Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.
Junqi NiuDepartment of Hepatology, First Hospital of Jilin University, Changchun, China.
Jing JiangDepartment of Clinical Research, First Hospital of Jilin University, Changchun, China.
First Hospital of Jilin University · CNJilin University · CNBeijing Chaoyang Emergency Medical Center · CNBeijing Jishuitan Hospital · CNPeking University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo investigate the association of interleukin (IL)-10 and IL-10 receptor A (IL-10RA) single nucleotide polymorphisms with the responsiveness to hepatitis B virus (HBV) vaccination in newborns whose mothers were hepatitis B surface antigen (HBsAg)(+)/hepatitis B e antigen (HBeAg)(-).

designNested case-control study.

settingChangchun, China.

participants713 infants from a Han Chinese population whose mothers were HBsAg(+)/HBeAg(-) and participated in the prevention of mother-to-child transmission of HBV at the First Hospital of Jilin University from July 2012 to July 2015 were included. Infants were excluded for HBsAg-positive; unstandardised vaccination process; inadequate blood samples; not Han Chinese and failed genotyping.

resultsInfants with artificial feeding pattern were correlated with low responsiveness to HBV vaccination (p=0.009). The GG genotype of IL-10 rs3021094 was correlated with a higher risk of low responsiveness to HBV vaccination (OR 2.80, 95% CI 1.35 to 5.83). No haplotype was found to be correlated with responsiveness to HBV vaccination. No gene-gene interaction was found between IL-10 and IL-10RA.

conclusionsOur study found that IL-10 gene variants were significantly associated with the immune response to the HBV vaccine. Identifying these high-risk infants who born to HBsAg(+)/HBeAg(-) mothers and low responses to hepatitis B vaccination will provide evidence for individualised prevention strategies.

Indexed as

Polymorphism, Single NucleotideAsian PeopleCase-Control StudiesChinaDNA, ViralFemaleGenotypeHepatitis BHepatitis B e AntigensHepatitis B Surface AntigensHepatitis B VaccinesHepatitis B virusHumansInfantInfant, NewbornInfectious Disease Transmission, VerticalDNA, ViralHepatitis B e AntigensHepatitis B Surface AntigensHepatitis B VaccinesIL10 protein, humanInterleukin-10Interleukin-10 Receptor alpha Subunitgeneticshepatobiliary diseaseimmunologyinfectious diseases

Identifiers

PMID30498038
PMCPMC6278805
OpenAlexW2903408539

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.