ArticleProceedings of the National Academy of Sciences of the United States of America2018
Genetic determinants and an epistasis of
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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51citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
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Who cites it
51 citing papers in PubMed, 87 citations in OpenAlex.
- Autoantibody-Based Models for the Diagnosis and Activity Assessment of Takayasu Arteritis.Journal of cardiovascular translational research · 2026Article
- The Effectiveness of Janus Kinase Inhibitors for the Management of Relapsing Takayasu Arteritis: A Spanish Real-World Study and Comprehensive Review of the Literature.Life (Basel, Switzerland) · 2026Article
- Exploring the Vasculitis-Tumors Link: Epidemiological Patterns, Mechanistic Insights, and Clinical Implications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Takayasu and Giant Cell Arteritis Unmasked by Vedolizumab as Paradoxical Reactions: Two Case Reports.ACR open rheumatology · 2026Article
- Association of genetic variants with extravascular complications and cytokine production in Takayasu arteritis: a cross-sectional study.Rheumatology advances in practice · 2026Article
- Validation of LILR antibody specificities and development of LILRA3-specific antibodies.Frontiers in immunology · 2026Article
- Advances in the pathophysiology, diagnosis and treatment of Takayasu arteritis.Nature reviews. Rheumatology · 2025Review
- Genome-wide epistasis analysis reveals significant epistatic signals associated with Parkinson's disease risk.Brain : a journal of neurology · 2025Article
- Granulocyte colony-stimulating factor-associated aortitis in a man with advanced prostate cancer.IJU case reports · 2025Article
- Functional and Practical Insights Into the Genetic Basis of Takayasu Arteritis.ACR open rheumatology · 2025Review
- Article
- A pilot study of childhood-onset Takayasu arteritis using whole exome sequencing suggests oligogenic inheritance involving classical complement, collagen, and autoinflammatory pathways.Clinical rheumatology · 2024Article
- Population genetic admixture and evolutionary history in the Shandong Peninsula inferred from integrative modern and ancient genomic resources.BMC genomics · 2024Article
- A Glimpse into Humoral Response and Related Therapeutic Approaches of Takayasu's Arteritis.International journal of molecular sciences · 2024Review
- Article
- Identification of the hybrid geneFrontiers in immunology · 2024Article
- Anti-integrin αvβ6 antibody in Takayasu arteritis patients with or without ulcerative colitis.Frontiers in immunology · 2024Article
- Fibrinogen induces inflammatory responses via the immune activating receptor LILRA2.Frontiers in immunology · 2024Article
- Ischemic stroke as the first clinical manifestation of an initially undiagnosed case of Takayasu arteritis in a young woman from Ethiopia: A case report.SAGE open medical case reports · 2024Article
- Successful Use of Tofacitinib in Refractory Takayasu Arteritis: A Case Series.Mediterranean journal of rheumatology · 2023Article
Corrections and comments
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Authors and funding
41 authors at 16 institutions in 2 countries.
Chikashi TeraoDepartment of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto, Kyoto 606-8507, Japan; a0001101@kuhp.kyoto-u.ac.jp.ORCID 0000-0002-6452-4095
Hajime YoshifujiDepartment of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto, Kyoto 606-8507, Japan.
Takayoshi MatsumuraDepartment of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan.
Taeko K NaruseDepartment of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.
Tomonori IshiiDepartment of Hematology and Rheumatology, Tohoku University School of Medicine, Sendai 980-8574, Japan.
Yoshikazu NakaokaDepartment of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita 565-0871, Japan.
Yohei KirinoDepartment of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.
Keitaro MatsuoDivision of Molecular and Clinical Epidemiology, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan.
Tomoki OriguchiNagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8501, Japan.
Masakazu ShimizuCenter for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.
Yasuhiro MaejimaDepartment of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.
Eisuke AmiyaDepartment of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan.
Natsuko TamuraDepartment of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.
Takahisa KawaguchiCenter for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.
Meiko TakahashiCenter for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.
Kazuya SetohCenter for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.
Koichiro OhmuraDepartment of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto, Kyoto 606-8507, Japan.
Ryu WatanabeDepartment of Hematology and Rheumatology, Tohoku University School of Medicine, Sendai 980-8574, Japan.
Tetsuya HoritaDivision of Rheumatology, Endocrinology and Nephrology, Hokkaido University Graduate School of Medicine, Sapporo 060-8648, Japan.
Tatsuya AtsumiDivision of Rheumatology, Endocrinology and Nephrology, Hokkaido University Graduate School of Medicine, Sapporo 060-8648, Japan.
Mitsuru MatsukuraDepartment of Surgical Oncology and Vascular Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan.
Tetsuro MiyataDepartment of Surgical Oncology and Vascular Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan.
Yuta KochiDepartment of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan.
Toshio SudaCancer Science Institute of Singapore, National University of Singapore, Singapore 117599.
Kazuo TanemotoDepartment of Cardiovascular Surgery, Kawasaki Medical School, Kurashiki 701-0192, Japan.
Akira MeguroDepartment of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokoham 236-0004, Japan.ORCID 0000-0002-9797-0948
Yukinori OkadaLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan.
Akiyoshi OgimotoDepartment of Cardiology, Pulmonology, Hypertension & Nephrology, Ehime University Graduate School of Medicine, Ehime 791-0295, Japan.
Motohisa YamamotoDepartment of Rheumatology, Sapporo Medical University School of Medicine, Sapporo Medical University, Sapporo 060-8556, Japan.
Hiroki TakahashiDepartment of Rheumatology, Sapporo Medical University School of Medicine, Sapporo Medical University, Sapporo 060-8556, Japan.
Shingo NakayamadaFirst Department of Internal Medicine, School of Medicine, University of Occupational & Environmental Health, Kitakyushu 807-8556, Japan.
Kazuyoshi SaitoFirst Department of Internal Medicine, School of Medicine, University of Occupational & Environmental Health, Kitakyushu 807-8556, Japan.
Masataka KuwanaDepartment of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, Tokyo 113-8603, Japan.
Nobuhisa MizukiDepartment of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokoham 236-0004, Japan.
Yasuharu TabaraCenter for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.
Atsuhisa UedaDepartment of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.
Issei KomuroDepartment of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan.
Akinori KimuraDepartment of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.
Mitsuaki IsobeDepartment of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.
Tsuneyo MimoriDepartment of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto, Kyoto 606-8507, Japan.
Fumihiko MatsudaCenter for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.
Kyoto University · JPThe University of Tokyo · JPTokyo Medical and Dental University · JPYokohama City University · JPHokkaido University · JPNational University of Singapore · SGSapporo Medical University · JPTohoku University · JPUniversity of Occupational and Environmental Health Japan · JPAichi Cancer Center · JPEhime University · JPKawasaki Medical School · JPNagasaki University · JPNational Cerebral and Cardiovascular Center · JPNippon Medical School · JPRIKEN Center for Integrative Medical Sciences · JP
Funding
No grant is acknowledged in the PubMed record.
Abstract
Takayasu arteritis (TAK) is a systemic vasculitis with severe complications that affects the aorta and its large branches. HLA-B*52 is an established susceptibility locus to TAK. To date, there are still only a limited number of reports concerning non-HLA susceptibility loci to TAK. We conducted a genome-wide association study (GWAS) and a follow-up study in a total of 633 TAK cases and 5,928 controls. A total of 510,879 SNPs were genotyped, and 5,875,450 SNPs were imputed together with HLA-B*52. Functional annotation of significant loci, enhancer enrichment, and pathway analyses were conducted. We identified four unreported significant loci, namely rs2322599, rs103294, rs17133698, and rs1713450, in
Indexed as
Epistasis, GeneticPolymorphism, Single NucleotideCase-Control StudiesCells, CulturedGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHLA-B52 AntigenHumansKiller Cells, NaturalReceptors, ImmunologicTakayasu ArteritisHLA-B*52:01 antigenHLA-B52 AntigenLILRA3 protein, humanReceptors, Immunologicautoimmunityepistasisgenome-wide association studyHLATakayasu arteritis
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.