ArticleAJNR. American journal of neuroradiology2018
MRI Evidence of Altered Callosal Sodium in Mild Traumatic Brain Injury.
Article in AJNR. American journal of neuroradiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 12 citations in OpenAlex.
- The Role of MRI in Debunking the Fallacy of "Mild" Traumatic Brain Injury.Journal of magnetic resonance imaging : JMRI · 2026Review
- Exploring Symptom Overlaps: Post-COVID-19 Neurological Syndrome and Post-Concussion Syndrome in Athletes.Biomedicines · 2024Review
- Neuroanatomical Substrates and Symptoms Associated With Magnetic Resonance Imaging of Patients With Mild Traumatic Brain Injury.JAMA network open · 2021Article
- The Molecular Pathophysiology of Concussion.Clinics in sports medicine · 2021Review
- Global decrease in brain sodium concentration after mild traumatic brain injury.Brain communications · 2021Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
background and purposeMild traumatic brain injury is a leading cause of death and disability worldwide with 42 million cases reported annually, increasing the need to understand the underlying pathophysiology because this could help guide the development of targeted therapy. White matter, particularly the corpus callosum, is susceptible to injury. Animal models suggest stretch-induced mechanoporation of the axonal membrane resulting in ionic shifts and altered sodium ion distribution. The purpose of this study was to compare the distribution of total sodium concentration in the corpus callosum between patients with mild traumatic brain injury and controls using sodium ( MATERIALS AND
methodsEleven patients with a history of mild traumatic brain injury and 10 age- and sex-matched controls underwent sodium (
resultsHigher total sodium concentration in the genu (49.28 versus 43.29 mmol/L,
conclusionsComplex differences are seen in callosal total sodium concentration in symptomatic patients with mild traumatic brain injury, supporting the notion of ionic dysfunction in the pathogenesis of mild traumatic brain injury. The total sodium concentration appears to be altered beyond the immediate postinjury phase, and further work is needed to understand the relationship to persistent symptoms and outcome.
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