Evidence map›Paper›PMID 30497846›Full record

ReviewAdvances in biological regulation2019

Intra- and intercellular trafficking in sphingolipid metabolism in myelination.

Binks W Wattenberg

Abstract readReview
In one paragraph

Review in Advances in biological regulation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Vitamin K: Infection, Inflammation, and Auto-Immunity.Journal of inflammation research · 2024
    Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Lung Lipidomic Alterations in Beagle Dogs Infected withAnimals : an open access journal from MDPI · 2022
    Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. TheeLife · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Binks W WattenbergDepartment of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine, Richmond, VA, 23298, USA. Electronic address: Brian.Wattenberg@vcuhealth.org.
Virginia Commonwealth University · US

Funding

Biochemistry and genetics of the ORMDL regulators of sphingolipid biosynthesisR01HL131340 · NHLBI · VIRGINIA COMMONWEALTH UNIVERSITY · PI WATTENBERG, BRIAN W. · 2016 to 2019
$1.5M
NHLBI NIH HHS R01 HL131340
6 · The paper itself

Abstract

The myelin sheath, produced by oligodendrocytes in the central nervous system, provides essential electrical insulation to neurons, but also is critical for viability of neurons. Both the protein and lipid composition of this fascinating membrane is unique. Here the focus is on the sphingolipids that are highly abundant in myelin and, in particular, how they are produced. This review discusses how sphingolipid metabolism is regulated. In particular the subcellular localization of lipid metabolic enzymes is discussed and how inter-organelle transport can affect the metabolic routes that sphingolipid precursors take. Understanding the regulation of sphingolipid metabolism in formation of the myelin membrane will have a significant impact on strategies to treat demyelinating diseases.

Indexed as

AnimalsBiological Transport, ActiveCentral Nervous SystemDemyelinating DiseasesHumansMyelin SheathOligodendrogliaSphingolipidsSphingolipids

Identifiers

PMID30497846
PMCPMC6469711
OpenAlexW2900595201

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.