ArticleJournal of biomechanics2019
An investigation of regional variations in the biaxial mechanical properties and stress relaxation behaviors of porcine atrioventricular heart valve leaflets.
Article in Journal of biomechanics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 55 citations in OpenAlex.
- Hyperelastic Cardiovascular NN-FE: A Framework for Integrating Nonlinear Finite Element Solvers with Neural Networks for the Hyperelastic Modeling of Cardiac Valve Tissue.Research square · 2026Article
- The Tricuspid Valve Maladapts in a Pulmonary Hypertension Rat Model.bioRxiv : the preprint server for biology · 2026Article
- Chordae Rupture Alters Tricuspid Valve Leaflet Biomechanics.Cardiovascular engineering and technology · 2026Article
- Tricuspid valve leaflet remodeling in sheep with biventricular heart failure: A comparison between leaflets.Acta biomaterialia · 2025Article
- FEBio FINESSE: An Open-Source Finite Element Simulation Approach to Estimate In Vivo Heart Valve Strains Using Shape Enforcement.Annals of biomedical engineering · 2025Article
- Analysis of Fluid-Structure Interaction Mechanisms for a Native Aortic Valve, Patient-Specific Ozaki Procedure, and a Bioprosthetic Valve.Annals of biomedical engineering · 2024Article
- Leaflet remodeling reduces tricuspid valve function in a computational model.Journal of the mechanical behavior of biomedical materials · 2024Article
- Bayesian Optimization-Based Inverse Finite Element Analysis for Atrioventricular Heart Valves.Annals of biomedical engineering · 2024Article
- MetaNO: How to Transfer Your Knowledge on Learning Hidden Physics.Computer methods in applied mechanics and engineering · 2023Article
- A Computational Pipeline for Patient-Specific Prediction of the Postoperative Mitral Valve Functional State.Journal of biomechanical engineering · 2023Article
- An investigation of how specimen dimensions affect biaxial mechanical characterizations with CellScale BioTester and constitutive modeling of porcine tricuspid valve leaflets.Journal of biomechanics · 2023Article
- Patient-Specific Quantitative In-Vivo Assessment of Human Mitral Valve Leaflet Strain Before and After MitraClip Repair.Cardiovascular engineering and technology · 2023Article
- A Physics-Guided Neural Operator Learning Approach to Model Biological Tissues From Digital Image Correlation Measurements.Journal of biomechanical engineering · 2022Article
- Benchtop characterization of the tricuspid valve leaflet pre-strains.Acta biomaterialia · 2022Article
- Texas TriValve 1.0 : a reverse‑engineered, open model of the human tricuspid valve.Engineering with computers · 2022Article
- Alterations in Human Mitral Valve Mechanical Properties Secondary to Left Ventricular Remodeling: A Biaxial Mechanical Study.Frontiers in cardiovascular medicine · 2022Article
- Parameterization, geometric modeling, and isogeometric analysis of tricuspid valves.Computer methods in applied mechanics and engineering · 2021Article
- Evaluation of affine fiber kinematics in porcine tricuspid valve leaflets using polarized spatial frequency domain imaging and planar biaxial testing.Journal of biomechanics · 2021Article
- The time has come to extend the expiration limit of cryopreserved allograft heart valves.Cell and tissue banking · 2021Review
- Manifold learning based data-driven modeling for soft biological tissues.Journal of biomechanics · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 5 institutions in 1 country.
Funding
Abstract
The facilitation of proper blood flow through the heart depends on proper function of heart valve components, and alterations to any component can lead to heart disease or failure. Comprehension of these valvular diseases is reliant on thorough characterization of healthy heart valve structures for use in computational models. Previously, computational models have treated these leaflet structures as a structurally and mechanically homogenous material, which may not be an accurate description of leaflet mechanical response. In this study, we aimed to characterize the mechanics of the heart valve leaflet as a structurally heterogenous material. Specifically, porcine mitral valve and tricuspid valve anterior leaflets were sectioned into six regions and biaxial mechanical tests with various loading ratios and stress-relaxation test were performed on each regional tissue sample. Three main findings from this study were summarized as follows: (i) the central regions of the leaflet had a more anisotropic nature than edge regions, (ii) the mitral valve anterior leaflet was more extensible in regions closer to the annulus, and (iii) there was variance in the stress-relaxation behavior among all six regions, with mitral valve leaflet tissue regions exhibiting a greater decay than the tricuspid valve regions. This study presents a novel investigation of the regional variations in the heart valve biomechanics that has not been comprehensively examined. Our results thus allow for a refinement of computational models for more accurately predicting diseased or surgically-intervened condition, where tissue heterogeneity plays an essential role in the heart valve function.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.