Mbd3 Promotes Reprogramming of Primary Human Fibroblasts.

Sajjida Jaffer, Pollyanna Goh, Mahnaz Abbasian, Amit C Nathwani

Open access · diamondAbstract read

In one paragraph

Article in International journal of stem cells, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it

0cells of the map it votes in

4citing papers in PubMed

0.3field-weighted citation impact, top 42% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

Synthetic genetic circuits to uncover the OCT4 trajectories of successful reprogramming of human fibroblasts.Science advances · 2023
Article
The NuRD complex cooperates with SALL4 to orchestrate reprogramming.Nature communications · 2023
Article
MAP2K6 remodels chromatin and facilitates reprogramming by activating Gatad2b-phosphorylation dependent heterochromatin loosening.Cell death and differentiation · 2022
Article
Episomal Induced Pluripotent Stem Cells: Functional and Potential Therapeutic Applications.Cell transplantation · 2019
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Sajjida JafferDepartment of Haematology, University College London, Cancer Institute, London, UK.

Pollyanna GohCentre for Paediatrics, Barts and The London Medical School, Blizard Institute, Queen Mary University of London, London, UK.

Mahnaz AbbasianDepartment of Haematology, University College London, Cancer Institute, London, UK.

Amit C NathwaniDepartment of Haematology, University College London, Cancer Institute, London, UK.

Royal Free London NHS Foundation Trust · GBNHS Blood and Transplant · GBQueen Mary University of London · GB

Funding

Medical Research Council MR/L022842/1

6 · The paper itself

Abstract

Mbd3 (Methyl-CpG binding domain protein), a core member of NuRD (nucleosome remodelling and deacetylation) is essential for embryogenesis. However, its role in reprogramming of somatic cells into induced pluripotent stem cells (iPSC) remains controversial. Some reports suggest that Mbd3 inhibits pluripotency, whilst others show that it greatly enhances reprogramming efficiency. Our study is the first to assess the role of

Indexed as

Episomal reprogrammingFibroblastsInduced pluripotent stem cellsMbd3

Identifiers

PMID30497130

DOI10.15283/ijsc18036

PMCPMC6285286

OpenAlexW2903093114

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.