Evidence map›Paper›PMID 30497128›Full record

ArticleInternational journal of stem cells2018

Hypoxic Preconditioned Mesenchymal Stromal Cell Therapy in a Rat Model of Renal Ischemia-reperfusion Injury: Development of Optimal Protocol to Potentiate Therapeutic Efficacy.

Myoung Jin Jang, Dalsan You, Jin Young Park, Kyung Kim, Joomin Aum, Chunwoo Lee, Geehyun Song, Ha Chul Shin, Nayoung Suh, Yong Man Kim and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of stem cells, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Review
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  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Locoregional delivery of stem cell-based therapies.Science translational medicine · 2020
    Review
  12. Review
  13. Review
  14. Review
  15. Surgically-induced brain injury: where are we now?Chinese neurosurgical journal · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Myoung Jin JangAsan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Dalsan YouDepartment of Urology, Asan Medical Institute of Convergence Science and Technology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Jin Young ParkDepartment of Urology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Kyung KimDepartment of Urology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Joomin AumDepartment of Urology, Asan Medical Institute of Convergence Science and Technology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Chunwoo LeeDepartment of Urology, Gyeongsang National University Changwon Hospital, Gyeongsang National University School of Medicine, Changwon, Korea.
Geehyun SongDepartment of Urology, Kangwon National University Hospital, Chuncheon, Korea.
Ha Chul ShinPharmicell Co. Ltd., Seongnam, Korea.
Nayoung SuhDepartment of Pharmaceutical Engineering, College of Medical Sciences, Soon Chun Hyang University, Asan, Korea.
Yong Man KimPharmicell Co. Ltd., Seongnam, Korea.
Choung-Soo KimDepartment of Urology, Asan Medical Institute of Convergence Science and Technology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although previous and ongoing clinical studies have used stromal cells during renal ischemia-reperfusion injury (IRI), there is little consensus regarding the optimal protocol. We aimed to optimize the protocol for hypoxic preconditioned human bone marrow-derived mesenchymal stromal cell (HP-hBMSC) therapy in a rat model of renal IRI. We determined the optimal injection route (renal arterial, renal parenchymal, and tail venous injection), dose (low-dose: 1×10

Indexed as

Acute kidney injuryCell therapyHypoxia preconditioningIschemia-reperfusion injuryRenal function

Identifiers

PMID30497128
PMCPMC6285294

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.