Trial reportEuropean heart journal2019
Differential effects of endurance, interval, and resistance training on telomerase activity and telomere length in a randomized, controlled study.
Trial report in European heart journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06732934 (The Effect of Basic Body Awareness Therapy and Aerobic Exercise Approaches on Telomere Length in Young Individuals), which is not on this map. Cited by 96 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Basic Body Awareness Therapy and Aerobic Exercise Approaches on Telomere Length in Young Individuals
Who cites it
96 citing papers in PubMed, 8 syntheses or guidelines pooled it, 197 citations in OpenAlex.
- Effects of acute, subacute, and chronic exercise on plasma s-Klotho levels: a systematic review and meta-analysis.Journal of physiology and biochemistry · 2026Pooled it
- Effects of Low-Intensity Endurance Training on Aerobic Fitness and Risk Factors of Cardiometabolic Health in Working-Age Adults: A Systematic Review and Meta-Analysis.Scandinavian journal of medicine & science in sports · 2026Pooled it
- The relationship between physical activity and telomere length in women: A systematic review.Mechanisms of ageing and development · 2025Pooled it
- Pooled it
- Exercise delays aging: evidence from telomeres and telomerase -a systematic review and meta-analysis of randomized controlled trials.Frontiers in physiology · 2025Pooled it
- Effects of Physical Exercise on Telomere Length in Healthy Adults: Systematic Review, Meta-Analysis, and Meta-Regression.JMIR public health and surveillance · 2024Pooled it
- Physical Activity on Telomere Length as a Biomarker for Aging: A Systematic Review.Sports medicine - open · 2022Pooled it
- Does Exercise Affect Telomere Length? A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Medicina (Kaunas, Lithuania) · 2022Pooled it
- Combined physical and cognitive training enhances telomere length in mild cognitive impairment patients.BMC geriatrics · 2026Trial
- Machine learning and data-driven inverse modeling of metabolomics unveil key processes of active aging.NPJ systems biology and applications · 2025Trial
- Trial
- The effects of early rehabilitation on functional exercise tolerance in decompensated heart failure patients: Results of a multicenter randomized controlled trial (ERIC-HF study).Clinical rehabilitation · 2022Trial
- Trial
- Telomere shortening associates with elevated insulin and nuchal fat accumulation.Scientific reports · 2020Trial
- Association of Short-term Change in Leukocyte Telomere Length With Cortical Thickness and Outcomes of Mental Training Among Healthy Adults: A Randomized Clinical Trial.JAMA network open · 2019Trial
- Acute cardiopulmonary responses to strength training, high-intensity interval training and moderate-intensity continuous training.European journal of applied physiology · 2019Trial
- Reframing Telomere Biology in Exercise Science: From Descriptive Metrics to Redox-Metabolic Mechanisms for Precision Healthy Aging (2000-2025).Biomedicines · 2026Review
- The impact of different intensities of physical activity on aging: A Mendelian randomization study.Medicine · 2026Article
- Chronic inflammation mediates the relationship between physical activity and telomere length.GeroScience · 2026Article
- The Impact of Weight Loss Secondary to Bariatric Surgery on Telomere Biology: A Narrative Review.Biomedicines · 2026Review
36 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aims: It is unknown whether different training modalities exert differential cellular effects. Telomeres and telomere-associated proteins play a major role in cellular aging with implications for global health. This prospective training study examines the effects of endurance training, interval training (IT), and resistance training (RT) on telomerase activity and telomere length (TL). Methods and results: One hundred and twenty-four healthy previously inactive individuals completed the 6 months study. Participants were randomized to three different interventions or the control condition (no change in lifestyle): aerobic endurance training (AET, continuous running), high-intensive IT (4 × 4 method), or RT (circle training on 8 devices), each intervention consisting of three 45 min training sessions per week. Maximum oxygen uptake (VO2max) was increased by all three training modalities. Telomerase activity in blood mononuclear cells was up-regulated by two- to three-fold in both endurance exercise groups (AET, IT), but not with RT. In parallel, lymphocyte, granulocyte, and leucocyte TL increased in the endurance-trained groups but not in the RT group. Magnet-activated cell sorting with telomerase repeat-ampliflication protocol (MACS-TRAP) assays revealed that a single bout of endurance training-but not RT-acutely increased telomerase activity in CD14+ and in CD34+ leucocytes. Conclusion: This randomized controlled trial shows that endurance training, IT, and RT protocols induce specific cellular pathways in circulating leucocytes. Endurance training and IT, but not RT, increased telomerase activity and TL which are important for cellular senescence, regenerative capacity, and thus, healthy aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.