ArticlePloS one2018
Global and regional trends of people living with HIV aged 50 and over: Estimates and projections for 2000-2020.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 167 papers, 6 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
167 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Association between HIV infection and type 2 diabetes mellitus: global incidence, prevalence, and risk factors - a systematic review and meta-analysis.BMC infectious diseases · 2025Pooled it
- Person-centred interventions to improve patient-provider relationships for HIV services in low- and middle-income countries: a systematic review.Journal of the International AIDS Society · 2024Pooled it
- A systematic review of engagement in care and health care utilization among older adults living with HIV and non-communicable diseases.AIDS care · 2022Pooled it
- Mental health and well-being of older adults living with HIV in sub-Saharan Africa: a systematic review.BMJ open · 2021Pooled it
- Aging with HIV in Latin America and the Caribbean: a Systematic Review.Current HIV/AIDS reports · 2021Pooled it
- Guideline
- Efficacy and safety of B/F/TAF in treatment-naïve and virologically suppressed people with HIV ≥ 50 years of age: integrated analysis from six phase 3 clinical trials.BMC infectious diseases · 2025Trial
- Patient-Reported Outcomes After Switching to a 2-Drug Regimen of Fixed-Dose Combination Dolutegravir/Lamivudine: 48-Week Results from the SALSA Study.AIDS and behavior · 2025Trial
- Blood and cerebrospinal fluid biomarker changes in patients with HIV-associated neurocognitive impairment treated with lithium: analysis from a randomised placebo-controlled trial.Journal of neurovirology · 2023Trial
- Acceptability of the Dapivirine Vaginal Ring in Postmenopausal US Women.AIDS patient care and STDs · 2022Trial
- HIV is associated with an increased risk of age-related clonal hematopoiesis among older adults.Nature medicine · 2021Trial
- Trial
- Global burden of disease attributable to unsafe sex among adults aged 60 years and older, 1990-2023: a secondary analysis of the global burden of disease study 2023.Annals of medicine · 2026Article
- Mosaic chromosomal alterations are suppressed in older adults with HIV.Communications biology · 2026Article
- Multidisciplinary Care for Older People With HIV: Optimizing Medication and Enhancing Quality of Life.Open forum infectious diseases · 2026Article
- Anticholinergic burden interacts with age and AIDS history to amplify frailty in people with HIV.British journal of clinical pharmacology · 2026Article
- Healthcare Acceptability and Delayed Care Among Older People Living with HIV in the All of Us Program.AIDS and behavior · 2026Article
- Relationship between self-perceptions of ageing and interoception among older people living with HIV: a latent profile analysis.BMC public health · 2026Article
- Intersecting Burdens: Pain and Psychosocial Stressors in Women with HIV and Type 2 Diabetes - Insights from the MACS/WIHS Combined Cohort Study.Research square · 2026Article
- Hypertension is a marker of the micro-epidemiologic transition in ageing HIV populations in Kenya, Uganda and Tanzania (AFRICOS, 2013-2023).BMC public health · 2026Article
107 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe increasing numbers of people living with HIV (PLHIV) who are receiving antiretroviral therapy (ART) have near normal life-expectancy, resulting in more people living with HIV over the age of 50 years (PLHIV50+). Estimates of the number of PLHIV50+ are needed for the development of tailored therapeutic and prevention interventions at country, regional and global level.
methodsThe AIDS Impact Module of the Spectrum software was used to compute the numbers of PLHIV, new infections, and AIDS-related deaths for PLHIV50+ for the years 2000-2016. Projections until 2020 were calculated based on an assumed ART scale-up to 81% coverage by 2020, consistent with the UNAIDS 90-90-90 treatment targets.
resultsGlobally, there were 5.7 million [4.7 million- 6.6 million] PLHIV50+ in 2016. The proportion of PLHIV50+ increased substantially from 8% in 2000 to 16% in 2016 and is expected to increase to 21% by 2020. In 2016, 80% of PLHIV50+ lived in low- and middle-income countries (LMICs), with Eastern and Southern Africa containing the largest number of PLHIV50+. While the proportion of PLHIV50+ was greater in high income countries, LMICs have higher numbers of PLHIV50+ that are expected to continue to increase by 2020.
conclusionsThe number of PLHIV50+ has increased dramatically since 2000 and this is expected to continue by 2020, especially in LMICs. HIV prevention campaigns, testing and treatment programs should also focus on the specific needs of PLHIV50+. Integrated health and social services should be developed to cater for the changing physical, psychological and social needs of PLHIV50+, many of whom will need to use HIV and non-HIV services.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.