ArticlePLoS pathogens2018
Soil humic acids degrade CWD prions and reduce infectivity.
Article in PLoS pathogens, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 33 citations in OpenAlex.
- Article
- Detection of chronic wasting disease prions in soil at an illegal white-tailed deer carcass disposal site.Prion · 2025Article
- RT-QuIC optimization for prion detection in soils.MethodsX · 2025Article
- Detection of chronic wasting disease prions in the farm soil of the Republic of Korea.mSphere · 2025Article
- Review
- Chronic Wasting Disease: State of the Science.Pathogens (Basel, Switzerland) · 2024Review
- Movement of Chronic Wasting Disease Prions in Prairie, Boreal and Alpine Soils.Pathogens (Basel, Switzerland) · 2023Article
- Biodegradation of bovine spongiform encephalopathy prions in compost.Scientific reports · 2022Article
- No evidence of uptake or propagation of reindeer CWD prions in environmentally exposed sheep.Acta veterinaria Scandinavica · 2022Article
- Chronic wasting disease - A prion disease through a One Health lens.The Canadian veterinary journal = La revue veterinaire canadienne · 2022Article
- Review
- Article
- Prion Dissemination through the Environment and Medical Practices: Facts and Risks for Human Health.Clinical microbiology reviews · 2021Review
- Review on PRNP genetics and susceptibility to chronic wasting disease of Cervidae.Veterinary research · 2021Review
- New and distinct chronic wasting disease strains associated with cervid polymorphism at codon 116 of the Prnp gene.PLoS pathogens · 2021Article
- Inactivation of Scrapie Prions by the Electrically Charged Disinfectant CAC-717.Pathogens (Basel, Switzerland) · 2020Article
- Long-Term Incubation PrPPathogens (Basel, Switzerland) · 2020Article
- The ecology of chronic wasting disease in wildlife.Biological reviews of the Cambridge Philosophical Society · 2020Review
- Cellulose ether treatment in vivo generates chronic wasting disease prions with reduced protease resistance and delayed disease progression.Journal of neurochemistry · 2020Article
- Differential gene expression in chronic wasting disease-positive white-tailed deer (Ecology and evolution · 2019Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Chronic wasting disease (CWD), an environmentally transmissible, fatal prion disease is endemic in North America, present in South Korea and has recently been confirmed in northern Europe. The expanding geographic range of this contagious disease of free-ranging deer, moose, elk and reindeer has resulted in increasing levels of prion infectivity in the environment. Soils are involved in CWD horizontal transmission, acting as an environmental reservoir, and soil mineral and organic compounds have the ability to bind prions. Upper horizons of soils are usually enriched with soil organic matter (SOM), however, the role of SOM in prion conservation and mobility remains unclear. In this study, we show that incubation of PrPCWD with humic acids (HA), a major SOM compound, affects both the molecular weight and recovery of PrPCWD. Detection of PrPCWD is reduced as HA concentration increases. Native HA extracted from pristine soils also reduces or entirely eliminates PrPCWD signal. Incubation of CWD prions with HA significantly increased incubation periods in tgElk mice demonstrating that HA can reduce CWD infectivity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.