ArticlePloS one2018
Altered intrinsic local activity and cognitive dysfunction in HIV patients: A resting-state fMRI study.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Implications and prospects of immunological and neuroimaging research in HIV-associated neurocognitive disorders.Frontiers in neurologyPooled it
- Resting-state functional connectivity in HIV - Findings from the ENIGMA HIV working group.Psychiatry research. Neuroimaging · 2026Article
- A rest-task fMRI study of spatial working memory in HIV-infected individuals across cognitive states.BMC medical imaging · 2026Article
- Diffusion tensor imaging-functional MRI fusion reveals disrupted white matter structure-function coupling in HIV-associated asymptomatic neurocognitive impairment.Frontiers in neuroscience · 2026Article
- Association between cognitive function, socio-clinical factors and biomarkers among Panamanian adults living with and without HIV: A cross-sectional study.Scientific reports · 2025Article
- Characteristics of cortical thickness in treated HIV-infected individuals with and without cognitive impairment.European journal of medical research · 2025Article
- Graph theory analysis reveals functional brain network alterations in HIV-associated asymptomatic neurocognitive impairment in virally suppressed homosexual males.BMC infectious diseases · 2025Article
- Altered angular gyrus activation during the digit symbol substitution test in people living with HIV: beyond information processing speed deficits.Scientific reports · 2025Article
- Alterations in local activity and whole-brain functional connectivity in human immunodeficiency virus-associated neurocognitive disorders: a resting-state functional magnetic resonance imaging study.Quantitative imaging in medicine and surgery · 2025Article
- Neuroimaging advances in neurocognitive disorders among HIV-infected individuals.Frontiers in neurology · 2025Review
- Divergent structural and functional brain alterations in HIV-infected patients: a multimodal meta-analysis.Frontiers in neurology · 2025Review
- Application status and prospects of multimodal EEG-fMRI in HIV-associated neurocognitive disorders.Frontiers in neurology · 2024Review
- Neurological, Behavioral, and Pathophysiological Characterization of the Co-Occurrence of Substance Use and HIV: A Narrative Review.Brain sciences · 2023Review
- Neurofunctional characteristics of executive control in older people with HIV infection: a comparison with Parkinson's disease.Brain imaging and behavior · 2022Article
- Altered regional homogeneity and functional connectivity of brain activity in young HIV-infected patients with asymptomatic neurocognitive impairment.Frontiers in neurology · 2022Article
- Frequency-dependent functional alterations in people living with HIV with early stage of HIV-associated neurocognitive disorder.Frontiers in neuroscience · 2022Article
- Altered Spontaneous Brain Activity Patterns of Meibomian Gland Dysfunction in Severely Obese Population Measured Using the Fractional Amplitude of Low-Frequency Fluctuations.Frontiers in psychiatry · 2022Article
- Prior Methamphetamine Use Disorder History Does Not Impair Interoceptive Processing of Soft Touch in HIV Infection.Viruses · 2021Article
- Alterations of Brain Signal Oscillations in Older Individuals with HIV Infection and Parkinson's Disease.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2021Article
- White matter of perinatally HIV infected older youths shows low frequency fluctuations that may reflect glial cycling.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
7 authors.
Funding
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Abstract
purposeTo characterize resting-state brain activation patterns and investigate altered areas for cognitive decline in HIV patients.
methodsTwelve male HIV patients with intact cognition (HIV-IC), 10 with HIV-associated neurocognitive disorder (HAND), and 11 male healthy controls (HC) underwent resting-state functional MRI (rsfMRI). Three rsfMRI values, regional homogeneity (ReHo), amplitude of low-frequency fluctuation (ALFF), and fractional ALFF (fALFF) were calculated and compared between groups. Correlation analyses were performed between rsfMRI values and neuropsychological tests.
resultsrsfMRI analyses revealed decreased rsfMRI values in the frontal areas, and increases in the posterior brain regions for both HIV-IC and HAND compared to HC. When directly compared to HIV-IC, HAND showed lower fALFF in the orbitofrontal cortex and higher ReHo in the primary sensorimotor area. Additionally, decreased orbitofrontal fALFF, increased sensorimotor ReHo, and a larger difference between the two values were highly correlated with decreased verbal memory and executive function in HIV patients.
conclusionsRegardless of cognitive status, altered local intrinsic activities were found in HIV patients. The orbitofrontal cortex and primary sensorimotor area were more disrupted in HAND relative to HIV-IC and correlated with behavioral performance, suggesting these areas are relevant to cognitive impairment in HIV patients.
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