ArticleeLife2018
Neural activity related to volitional regulation of cortical excitability.
Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Investigating the Use of a Brain-computer Interface Based on TMS Neurofeedback for Upper Limb Stroke Rehabilitation
Assessing and Modeling the Mechanisms of Recovery During Robot Aided Neurorehabilitation of Walking
Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Comparative efficacy of different modalities of transcranial magnetic stimulation for treating Parkinson's disease with depression: a systematic review and network meta-analysis.Frontiers in neurology · 2025Pooled it
- Motor Cortex Reorganization in Limb Amputation: A Systematic Review of TMS Motor Mapping Studies.Frontiers in neuroscience · 2020Pooled it
- Self-modulation of motor cortex activity after stroke: a randomized controlled trial.Brain : a journal of neurology · 2022Trial
- AI-Driven Hemodynamic Detection of Self-Induced Daydreaming With EMG-Based Physiological Triggers During Pre- and Post-Prandial States Using fNIRS and EGG.CNS neuroscience & therapeutics · 2026Article
- Brain-computer interface-based neurofeedback training enables transferable control of cortical state switching in humans.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- TMS-Based Neurofeedback Training of Mental Finger Individuation Induces Neuroplastic Changes in the Sensorimotor System.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Modulating cortical excitability and cortical arousal by pupil self-regulation.Nature communications · 2025Article
- Enhanced human sensorimotor integration via self-modulation of the somatosensory activity.iScience · 2025Article
- EEG decoding with spatiotemporal convolutional neural network for visualization and closed-loop control of sensorimotor activities: A simultaneous EEG-fMRI study.Human brain mapping · 2024Article
- Self-regulating arousal via pupil-based biofeedback.Nature human behaviour · 2024Article
- Neurofeedback-induced desynchronization of sensorimotor rhythm elicits pre-movement downregulation of intracortical inhibition that shortens simple reaction time in humans: A double-blind, sham-controlled randomized study.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Article
- Neuron matters: neuromodulation with electromagnetic stimulation must consider neurons as dynamic identities.Journal of neuroengineering and rehabilitation · 2022Review
- Article
- Dynamic responses of neurons in different states under magnetic field stimulation.Journal of computational neuroscience · 2022Article
- Stimulation artifact source separation (SASS) for assessing electric brain oscillations during transcranial alternating current stimulation (tACS).NeuroImage · 2021Article
- A Study on the Effect of Mental Practice Using Motor Evoked Potential-Based Neurofeedback.Frontiers in human neuroscience · 2021Article
- Challenges and Opportunities for the Future of Brain-Computer Interface in Neurorehabilitation.Frontiers in neuroscience · 2021Review
- Could Brain-Computer Interface Be a New Therapeutic Approach for Body Integrity Dysphoria?Frontiers in human neuroscience · 2021Review
- Post-stroke Rehabilitation of Severe Upper Limb Paresis in Germany - Toward Long-Term Treatment With Brain-Computer Interfaces.Frontiers in neurology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
To date there exists no reliable method to non-invasively upregulate or downregulate the state of the resting human motor system over a large dynamic range. Here we show that an operant conditioning paradigm which provides neurofeedback of the size of motor evoked potentials (MEPs) in response to transcranial magnetic stimulation (TMS), enables participants to self-modulate their own brain state. Following training, participants were able to robustly increase (by 83.8%) and decrease (by 30.6%) their MEP amplitudes. This volitional up-versus down-regulation of corticomotor excitability caused an increase of late-cortical disinhibition (LCD), a TMS derived read-out of presynaptic GABA
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.