Evidence map›Paper›PMID 30489078›Full record

ArticleJournal of natural products2018

Isolation and Characterization of Anaephenes A-C, Alkylphenols from a Filamentous Cyanobacterium ( Hormoscilla sp., Oscillatoriales).

David Brumley, Kara A Spencer, Sarath P Gunasekera, Thomas Sauvage, Jason Biggs, Valerie J Paul, Hendrik Luesch

Abstract read
In one paragraph

Article in Journal of natural products, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

David Brumley
Kara A Spencer
Sarath P GunasekeraSmithsonian Marine Station at Ft. Pierce , 701 Seaway Drive , Ft. Pierce , Florida 34949 , United States.
Thomas SauvageSmithsonian Marine Station at Ft. Pierce , 701 Seaway Drive , Ft. Pierce , Florida 34949 , United States.
Jason BiggsUniversity of Guam Marine Laboratory , Mangilao , Guam 96923 , United States.
Valerie J PaulSmithsonian Marine Station at Ft. Pierce , 701 Seaway Drive , Ft. Pierce , Florida 34949 , United States.ORCID 0000-0002-4691-1569

Funding

Novel Targeted Anticancer Agents from Marine CyanobacteriaR01CA172310 · NCI · UNIVERSITY OF FLORIDA · PI HENDRIK LUESCH · 2013 to 2026
$5.8M
NCI NIH HHS R01 CA172310
6 · The paper itself

Abstract

Three related new alkylphenols, termed anaephenes A-C (1-3), containing different side chains, were isolated from an undescribed filamentous cyanobacterium (VPG 16-59) collected in Guam. Our 16S rDNA sequencing efforts indicated that VPG 16-59 is a member of the marine genus Hormoscilla (Oscillatoriales). The structures of anaephenes A-C (1-3) were elucidated by spectroscopic methods, and compounds assayed for growth inhibitory activity against prokaryotic and eukaryotic cell lines. Anaephene B (2), possessing a terminal alkyne, displayed moderate activity against Bacillus cereus and Staphylococcus aureus with MIC values of 6.1 μg/mL. While 1 and 3 showed no pronounced activity in these assays, their structural features highlight the unusual biosynthetic capacity of this cyanobacterium and warrant further study.

Indexed as

Anti-Bacterial AgentsAntifungal AgentsBacillus cereusCell SurvivalCyanobacteriaHCT116 CellsHumansMolecular StructurePhenolsSpectrum AnalysisStaphylococcus aureusAnti-Bacterial AgentsAntifungal AgentsPhenols

Identifiers

PMID30489078
PMCPMC7315913

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.