Evidence map›Paper›PMID 30488973›Full record

ArticleScandinavian journal of immunology2019

Antigen-specific CD8 T cells in cell cycle circulate in the blood after vaccination.

Sonia Simonetti, Ambra Natalini, Antonella Folgori, Stefania Capone, Alfredo Nicosia, Angela Santoni, Francesca Di Rosa

Open access · hybridAbstract read
In one paragraph

Article in Scandinavian journal of immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. COVID-19: Using high-throughput flow cytometry to dissect clinical heterogeneity.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2023
    Review
  4. Article
  5. OMIP-079: Cell cycle of CD4Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2021
    Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Sonia SimonettiInstitute of Molecular Biology and Pathology, National Research Council (CNR), Rome, Italy.
Ambra NataliniInstitute of Molecular Biology and Pathology, National Research Council (CNR), Rome, Italy.
Antonella FolgoriReithera S.r.l., Rome, Italy.
Stefania CaponeReithera S.r.l., Rome, Italy.
Alfredo NicosiaKeires AG, Basel, Switzerland.
Angela SantoniInstitute of Molecular Biology and Pathology, National Research Council (CNR), Rome, Italy.
Francesca Di RosaInstitute of Molecular Biology and Pathology, National Research Council (CNR), Rome, Italy.ORCID https://orcid.org/0000-0003-0252-9138
Institute of Molecular Biology and Pathology · ITKyocera (United States) · USCeinge Biotecnologie Avanzate (Italy) · IT

Funding

Associazione Italiana Ricerca sul Cancro (AIRC) 5 x 1000 grantMinistero dell'Università e delle Ricerca (MIUR) CTN01_00177_962865 (Medintech) grantReithera grant in 2017 and 2018
6 · The paper itself

Abstract

Although clonal expansion is a hallmark of adaptive immunity, the location(s) where antigen-responding T cells enter cell cycle and complete it have been poorly explored. This lack of knowledge stems partially from the limited experimental approaches available. By using Ki67 plus DNA staining and a novel strategy for flow cytometry analysis, we distinguished antigen-specific CD8 T cells in G

Indexed as

Blood CirculationAdaptive ImmunityAnimalsAntigensCD8-Positive T-LymphocytesCell CycleCell ProliferationCell SurvivalDNAFemaleFlow CytometryGenetic VectorsHEK293 CellsHumansKi-67 AntigenLymph NodesAntigensDNAKi-67 Antigenantigen-specific responsebloodclonal expansionflow cytometry analysisspleen and lymph nodesT cellsvaccinationviral vectors

Identifiers

PMID30488973
PMCPMC6850756
OpenAlexW2902588119

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.