ArticleMedical science monitor : international medical journal of experimental and clinical research2018
Gut Microbiota Disruption in Septic Shock Patients: A Pilot Study.
Article in Medical science monitor : international medical journal of experimental and clinical research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Difference analysis of intestinal microbiota in patients in the intensive care unit using different sampling methods: a systematic review and meta-analysis.Frontiers in microbiology · 2025Pooled it
- Gut microbiota dysbiosis in patients with sepsis: a meta-analysis of microbial diversity and taxonomic abundance.Infection · 2026Review
- [Association between the structure of intestinal flora and inflammatory response in children with sepsis: a prospective cohort study].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024Article
- Analysis of fecal microbiota and related clinical indicators in ICU patients with sepsis.Heliyon · 2024Article
- Regulatory effects of mangiferin on LPS-induced inflammatory responses and intestinal flora imbalance during sepsis.Food science & nutrition · 2024Article
- Profiling the diversity of the village chicken faecal microbiota using 16S rRNA gene and metagenomic sequencing data to reveal patterns of gut microbiome signatures.Frontiers in microbiology · 2024Article
- Investigating gut microbiota-blood and urine metabolite correlations in early sepsis-induced acute kidney injury: insights from targeted KEGG analyses.Frontiers in cellular and infection microbiology · 2024Observational
- Gut microbiota and sepsis and sepsis-related death: a Mendelian randomization investigation.Frontiers in immunology · 2024Article
- Gut Microbiome-Based Therapeutics in Critically Ill Adult Patients-A Narrative Review.Nutrients · 2023Review
- The Role of Gut Microbiota in the Clinical Outcome of Septic Patients: State of the Art and Future Perspectives.International journal of molecular sciences · 2023Review
- Lower gut dysbiosis and mortality in acute critical illness: a systematic review and meta-analysis.Intensive care medicine experimental · 2023Article
- Role of gut microbiota and bacterial translocation in acute intestinal injury and mortality in patients admitted in ICU for septic shock.Frontiers in cellular and infection microbiology · 2023Article
- The central and biodynamic role of gut microbiota in critically ill patients.Critical care (London, England) · 2022Review
- Contribution of gut microbiota toward renal function in sepsis.Frontiers in microbiology · 2022Review
- Association Between Gut Dysbiosis and Sepsis-Induced Myocardial Dysfunction in Patients With Sepsis or Septic Shock.Frontiers in cellular and infection microbiology · 2022Observational
- Enteral feeding and the microbiome in critically ill children: a narrative review.Translational pediatrics · 2021Review
- The Effects of Chinese Medicine QRD, Antibiotics, and Probiotics on Therapy and Gut Microbiota in Septic Rats.Frontiers in cellular and infection microbiology · 2021Article
- Low-Abundant Microorganisms: The Human Microbiome's Dark Matter, a Scoping Review.Frontiers in cellular and infection microbiology · 2021Article
- The Specific Bile Acid Profile of Shock: A Hypothesis Generating Appraisal of the Literature.Journal of clinical medicine · 2020Article
- Gut microbiota profiles in critically ill patients, potential biomarkers and risk variables for sepsis.Gut microbes · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND The composition of the intestinal microbiota and its effect on septic shock patients in the intensive care unit (ICU) is unknown. In the present study we explored the hypothesis that bacterial diversity is decreased in septic shock patients and that this diversity may be improved by use of probiotics or enteral nutrition. MATERIAL AND METHODS A total of 15 stool samples were collected prospectively from septic shock patients in the ICU, while 15 samples from healthy subjects served as controls. Bacterial DNA was submitted for 16S rDNA gene sequencing. The relationship between intestinal microbiota and prognosis was evaluated. RESULTS Significantly lower bacterial diversity was found in septic shock patients compared with healthy subjects (p<0.05). However, there was no difference in bacterial diversity in the presence or absence of probiotics (p=0.59), enteral nutrition (p=0.59), or in-hospital death (p=0.93) in septic shock patients. A high abundance of Proteobacteria and Fusobacteria was observed in most septic shock patients, whereas low abundance was observed in healthy subjects (mean relative proportion: 23.71% vs. 3.53%, p<0.05; 1.27% vs. 0.12%, p=0.59). CONCLUSIONS Bacterial diversity was decreased, and 1 or 2 rare bacterial species were overgrown in septic shock patients. Bacterial diversity was not improved by use of probiotics or enteral nutrition. The small sample size of our study limits the interpretation of results.
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