Evidence map›Paper›PMID 30488769›Full record

ArticleJournal of biomolecular structure & dynamics2019

Design of inhibitors of thymidylate kinase from

Danielle Rodrigues Garcia, Felipe Rodrigues de Souza, Ana Paula Guimarães, Teodorico Castro Ramalho, Alcino Palermo de Aguiar, Tanos Celmar Costa França

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biomolecular structure & dynamics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Mpox (formerly monkeypox): pathogenesis, prevention, and treatment.Signal transduction and targeted therapy · 2023
    Review
  3. The 2022 monkeypox outbreak: Lessons from the 640 cases in 36 countries.International journal of surgery (London, England) · 2022
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Danielle Rodrigues GarciaLaboratory of Molecular Modeling Applied to Chemical and Biological Defense, Military Institute of Engineering , Rio de Janeiro , RJ , Brazil.
Felipe Rodrigues de SouzaLaboratory of Molecular Modeling Applied to Chemical and Biological Defense, Military Institute of Engineering , Rio de Janeiro , RJ , Brazil.
Ana Paula GuimarãesDepartment of Chemistry, Federal University of Viçosa , Viçosa , MG , Brazil.
Teodorico Castro RamalhoLaboratory of Computational Chemistry, Department of Chemistry, UFLA , Lavras , MG , Brazil.ORCID 0000-0002-7324-1353
Alcino Palermo de AguiarLaboratory of Organic Synthesis, Military Institute of Engineering , Rio de Janeiro , RJ , Brazil.
Tanos Celmar Costa FrançaLaboratory of Molecular Modeling Applied to Chemical and Biological Defense, Military Institute of Engineering , Rio de Janeiro , RJ , Brazil.ORCID 0000-0002-6048-8103
Military Institute of Engineering · BRUniversidade Federal de Lavras · BRUniversidade Federal de Viçosa · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acknowledging the importance of studies toward the development of measures against terrorism and bioterrorism, this study aims to contribute to the design of new prototypes of potential drugs against smallpox. Based on a former study, nine synthetic feasible prototypes of selective inhibitors for thymidylate kinase from

Indexed as

Drug DesignEnzyme InhibitorsHumansLigandsMolecular Docking SimulationMolecular Dynamics SimulationNucleoside-Phosphate KinaseSmallpoxThermodynamicsVariola virusdTMP kinaseEnzyme InhibitorsLigandsNucleoside-Phosphate KinasedockingDrug designmolecular dynamics simulationssmallpoxthymidylate kinaseVariola virus

Identifiers

PMID30488769
PMCPMC9491145
OpenAlexW2903546957

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.