ArticleBrain and behavior2019
Accelerated age-related cortical thinning in mild traumatic brain injury.
Article in Brain and behavior, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Surface-based morphometry reveals divergent aging trajectories in veterans with and without traumatic brain injury.GeroScience · 2026Article
- Changes in brain morphology over the first year in adult mixed-mechanism mild traumatic brain injury: the role of injury severity factors.NeuroImage. Clinical · 2026Article
- BDNF genotype associated with changes in cortical thickness, severity of symptoms, and cognitive impairments in mild traumatic brain injury.Molecular brain · 2025Article
- Abnormal brain morphology and morphological brain network in adults with acute mild traumatic brain injury.Neuroreport · 2025Article
- Unsupervised semi-automated MRI segmentation detects cortical lesion expansion in chronic traumatic brain injury.Frontiers in neurology · 2025Article
- APOE4 and age affect the brain entorhinal cortex structure and blood arachidonic acid and docosahexaenoic acid levels after mild TBI.Scientific reports · 2024Article
- History of traumatic brain injury is associated with increased grey-matter loss in patients with mild cognitive impairment.Journal of neurology · 2024Article
- The Effects of Early Life History of TBI on the Progression of Normal Brain Aging with Implications for Increased Dementia Risk.Advances in neurobiology · 2024Review
- Military-related mild traumatic brain injury: clinical characteristics, advanced neuroimaging, and molecular mechanisms.Translational psychiatry · 2023Review
- Traumatic brain injury alters the relationship between brain structure and episodic memory.Brain and behavior · 2023Article
- Genetic Risk for Alzheimer Disease and Plasma Tau Are Associated With Accelerated Parietal Cortex Thickness Change in Middle-Aged Adults.Neurology. Genetics · 2023Article
- Modified constraint-induced movement therapy enhances cortical plasticity in a rat model of traumatic brain injury: a resting-state functional MRI study.Neural regeneration research · 2023Article
- Functional brain activity constrained by structural connectivity reveals cohort-specific features for serum neurofilament light chain.Communications medicine · 2022Article
- Social Support Buffers Against Cognitive Decline in Single Mild Traumatic Brain Injury With Loss of Consciousness: Results From the Canadian Longitudinal Study on Aging.The journals of gerontology. Series B, Psychological sciences and social sciences · 2021Article
- Synergistic effects of brain injury and aging: common mechanisms of proteostatic dysfunction.Trends in neurosciences · 2021Review
- Acute cognitive impairment after traumatic brain injury predicts the occurrence of brain atrophy patterns similar to those observed in Alzheimer's disease.GeroScience · 2021Article
- Group characterization of impact-induced,Journal of the Royal Society, Interface · 2021Article
- Repetitive mTBI is associated with age-related reductions in cerebral blood flow but not cortical thickness.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
- Article
- MRI Volumetric Quantification in Persons with a History of Traumatic Brain Injury and Cognitive Impairment.Journal of Alzheimer's disease : JAD · 2019Article
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4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionMild traumatic brain injury (mTBI) can result in many structural abnormalities in the cerebral cortex. While thinning of the cortex has been shown in mTBI patients, there is high regional variability in reported findings. High-resolution imaging can elucidate otherwise unnoticed changes in cortical measures following injury. This study examined age-related patterns of cortical thickness in U.S. active duty service members and veterans with a history of mTBI (n = 66) as compared to a normative population (n = 67).
methodsUsing a fully automated cortical parcellation methodology, cortical thickness measures were extracted from 31 bilateral cortical regions for all participants.
resultsThe effect of diagnosis and age on cortical thickness (group × age interaction) was found to be significant (p < 0.05) for many regions, including bilateral parietal and left frontal and temporal cortices. Findings held for a male-only subset, and there was no effect of time since injury in any regions.
conclusionsThe presence of mTBI appeared to accelerate age-related cortical thinning across the cortex in our study population.
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