ArticleBrain and behavior2019
Resting-state functional brain networks in adults with a new diagnosis of focal epilepsy.
Article in Brain and behavior, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05450822 (The BrainDrugs-Epilepsy Study), which is not on this map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The BrainDrugs-Epilepsy Study: A Prospective Open-label Cohort Precision Medicine Study in Epilepsy
Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Structural brain imaging biomarkers for predicting seizure recurrence after a first unprovoked seizure.Epilepsia open · 2026Article
- Network dysfunction underlying verbal fluency deficits in newly diagnosed epilepsy: a resting-state fMRI functional connectivity study.BMC medicine · 2025Article
- Altered Effective Connectivity of the Attentional Network in Temporal Lobe Epilepsy with EEG Data.Bioengineering (Basel, Switzerland) · 2025Article
- Longitudinal alterations in brain networks and thalamocortical connectivity in paediatric focal epilepsy: a structural connectomics pilot study.Brain communications · 2025Article
- Effect of Antiseizure Medication on the Salience Network in Patients with Epilepsy with Generalized Tonic-Clonic Seizures Alone.Biomedicines · 2024Article
- Article
- Altered resting state functional connectivity in youth with congenital heart disease operated during infancy.PloS one · 2022Article
- Probabilistic mapping of thalamic nuclei and thalamocortical functional connectivity in idiopathic generalised epilepsy.Human brain mapping · 2021Article
- Regional abnormality of functional connectivity is associated with clinical manifestations in individuals with intractable focal epilepsy.Scientific reports · 2021Article
- Altered structural connectome in non-lesional newly diagnosed focal epilepsy: Relation to pharmacoresistance.NeuroImage. Clinical · 2021Article
- Article
- Resting-state brain functional connectivity in patients with chronic pain who responded to subanesthetic-dose ketamine.Scientific reports · 2019Article
- Recent developments in imaging of epilepsy.Current opinion in neurology · 2019Review
- Resting-state functional brain networks in adults with a new diagnosis of focal epilepsy.Brain and behavior · 2019Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
objectivesNewly diagnosed focal epilepsy (NDfE) is rarely studied, particularly using advanced neuroimaging techniques. Many patients with NDfE experience cognitive impairments, particularly with respect to memory, sustained attention, mental flexibility, and executive functioning. Cognitive impairments have been related to alterations in resting-state functional brain networks in patients with neurological disorders. In the present study, we investigated whether patients with NDfE had altered connectivity in large-scale functional networks using resting-state functional MRI.
methodsWe recruited 27 adults with NDfE and 36 age- and sex-matched healthy controls. Resting-state functional MRI was analyzed using the Functional Connectivity Toolbox (CONN). We investigate reproducibly determined large-scale functional networks, including the default mode, salience, fronto-parietal attention, sensorimotor, and language networks using a seed-based approach. Network comparisons between patients and controls were thresholded using a FDR cluster-level correction approach.
resultsWe found no significant differences in functional connectivity between seeds within the default mode, salience, sensorimotor, and language networks and other regions of the brain between patients and controls. However, patients with NDfE had significantly reduced connectivity between intraparietal seeds within the fronto-parietal attention network and predominantly frontal and temporal cortical regions relative to controls; this finding was demonstrated including and excluding the patients with brain lesions. No common alteration in brain structure was observed in patients using voxel-based morphometry. Findings were not influenced by treatment outcome at 1 year.
conclusionsPatients with focal epilepsy have brain functional connectivity alterations at diagnosis. Functional brain abnormalities are not necessarily a consequence of the chronicity of epilepsy and are present when seizures first emerge.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.