ArticleAging cell2019
Disrupted-in-schizophrenia-1 protects synaptic plasticity in a transgenic mouse model of Alzheimer's disease as a mitophagy receptor.
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Article in Aging cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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62citing papers in PubMed
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62 citing papers in PubMed, 90 citations in OpenAlex.
- Beyond Histamine Blockade: Clemastine Fumarate as a Promoter of Myelin Regeneration, Inflammatory Regulation, and Neuroimmune Modulation in CNS Disorders.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2026Review
- DISC1 Orchestrates Mitochondrial Calcium Overload in Diabetic Encephalopathy Through a Dual Nucleocytoplasmic Mechanism.Biomolecules · 2026Article
- Distinct Transcriptional States of TDP-43 Pathology in an Alzheimer's Disease Mouse Model.Neuroscience bulletin · 2026Article
- The miR-335-5p/DKK1/autophagy axis regulates TNF-α-mediated dysfunction of dental pulp stem cells.In vitro cellular & developmental biology. Animal · 2026Article
- Post-translational modifications of selective autophagy receptors: orchestrating cellular homeostasis, disease pathogenesis, and therapeutic opportunities.Cellular & molecular biology letters · 2026Review
- Autophagy and Neuropsychiatric Disorders: Unraveling Molecular Mechanisms and Signaling Pathways.CNS & neurological disorders drug targets · 2026Review
- Icariside II protects against neuronal injury by modulating PI3K/AKT-dependent mitochondrial dynamics and apoptosis in Alzheimer's disease models.Frontiers in pharmacology · 2026Article
- DISC1 Protects Against Zika Virus Infection and Long-Term Neurological Damage Through AMPK-mTOR-Mediated Autophagy.Nature communications · 2025Article
- Impaired macroautophagy in oligodendrocyte precursor cells suppresses neuronal plasticity via a senescence-associated signaling.Science advances · 2025Article
- Endothelial delivery of simvastatin by LRP1-targeted nanoparticles ameliorates pathogenesis of alzheimer's disease in a mouse model.Alzheimer's research & therapy · 2025Article
- Therapeutic potential of melatonin-induced mitophagy in the pathogenesis of Alzheimer's disease.Inflammopharmacology · 2025Review
- Mitophagy's impacts on cancer and neurodegenerative diseases: implications for future therapies.Journal of hematology & oncology · 2025Review
- Role of Mitochondrial Dysfunctions in Neurodegenerative Disorders: Advances in Mitochondrial Biology.Molecular neurobiology · 2025Review
- Organellophagy regulates cell death:A potential therapeutic target for inflammatory diseases.Journal of advanced research · 2025Review
- Mitochondrial dysfunction in Alzheimer's disease: Guiding the path to targeted therapies.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Review
- Multi-omics insights into the role of mitophagy receptor-related genes in glioma prognosis and immune microenvironment remodeling.Frontiers in immunology · 2025Article
- Functional Relationships between L1CAM, LC3, ATG12, and Aβ.International journal of molecular sciences · 2024Article
- Strategic targeting of miR-183 and β-catenin to enhance BMSC stemness in age-related osteoporosis therapy.Scientific reports · 2024Article
- GPR50 regulates neuronal development as a mitophagy receptor.Cell death & disease · 2024Article
- Altered synaptic currents, mitophagy, mitochondrial dynamics in Alzheimer's disease models and therapeutic potential of Dengzhan Shengmai capsules intervention.Journal of pharmaceutical analysis · 2024Article
2 more citing papers are in PubMed but not listed here.
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Authors and funding
19 authors at 9 institutions in 3 countries.
Zhao-Tao WangDepartment of Neurosurgery, Affiliated Bayi Brain Hospital, General Army Hospital, Southern Medical University, Beijing, China.
Mei-Hong LuJiangsu Key Laboratory of Neuropsychiatric Diseases, Institute of Neuroscience, Soochow University, Suzhou, China.
Yan ZhangDepartment of Neurosurgery, Affiliated Bayi Brain Hospital, General Army Hospital, Southern Medical University, Beijing, China.
Wen-Li JiJiangsu Key Laboratory of Neuropsychiatric Diseases, Institute of Neuroscience, Soochow University, Suzhou, China.
Lei LeiDepartment of Physiology, Liaoning Provincial Key Laboratory of Cerebral Diseases, Dalian Medical University, Dalian, China.
Wang WangJiangsu Key Laboratory of Neuropsychiatric Diseases, Institute of Neuroscience, Soochow University, Suzhou, China.
Li-Pao FangJiangsu Key Laboratory of Neuropsychiatric Diseases, Institute of Neuroscience, Soochow University, Suzhou, China.
Lu-Wen WangDepartment of Pathology, Case Western Reserve University, Cleveland, Ohio.
Fan YuJiangsu Key Laboratory of Neuropsychiatric Diseases, Institute of Neuroscience, Soochow University, Suzhou, China.
Ji WangDepartment of Neurosurgery, Affiliated Bayi Brain Hospital, General Army Hospital, Southern Medical University, Beijing, China.
Zhen-Yu LiDepartment of Neurosurgery, Affiliated Bayi Brain Hospital, General Army Hospital, Southern Medical University, Beijing, China.
Jian-Rong WangHematology Center of Cyrus Tang Medical Institute, Collaborative Innovation Center of Hematology, Key Laboratory of Stem Cells and Biomedical, Materials of Jiangsu Province and Chinese Ministry of Science and Technology, State Key Laboratory of Radiation Medicine and Radioprotection, Soochow University School of Medicine, Suzhou, China.
Ting-Hua WangInstitute of Neuroscience, Kunming Medical University, Kunming, China.
Fei DouCollege of Life Sciences, Beijing Normal University, Beijing, China.
Qin-Wen WangNingbo Key Laboratory of Behavioral Neuroscience, Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, China.
Xing-Long WangDepartment of Pathology, Case Western Reserve University, Cleveland, Ohio.
Shao LiDepartment of Physiology, Liaoning Provincial Key Laboratory of Cerebral Diseases, Dalian Medical University, Dalian, China.
Quan-Hong MaJiangsu Key Laboratory of Neuropsychiatric Diseases, Institute of Neuroscience, Soochow University, Suzhou, China.
Ru-Xiang XuDepartment of Neurosurgery, Affiliated Bayi Brain Hospital, General Army Hospital, Southern Medical University, Beijing, China.
Soochow University · CNBayi Children's Hospital · CNCase Western Reserve University · USDalian Medical University · CNMinistry of Education · BDSouthern Medical University · CNBeijing Normal University · CNKunming Medical University · CNNingbo University · CN
Funding
Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases BM2013003Jiangsu Provincial Special Program of Medical Science BL2014042Military Medical Science Research Project 16CXZ001National Natural Science Foundation of China 16CXZ001National Natural Science Foundation of China 81870897National Natural Science Foundation of China BK20150347National Natural Science Foundation of China BL2014042National Natural Science Foundation of China BM2013003National Natural Science Foundation of China ZDXKB2016022National Program on Key Basic Research Project 2013CB945602Suzhou Clinical Research Center of Neurological Disease Szzx201503
Abstract
Mitochondrial dysfunction is an early feature of Alzheimer's disease (AD). Accumulated damaged mitochondria, which are associated with impaired mitophagy, contribute to neurodegeneration in AD. We show levels of Disrupted-in-schizophrenia-1 (DISC1), which is genetically associated with psychiatric disorders and AD, decrease in the brains of AD patients and transgenic model mice and in Aβ-treated cultured cells. Disrupted-in-schizophrenia-1 contains a canonical LC3-interacting region (LIR) motif (
Indexed as
MitophagyNeuronal PlasticityAlzheimer DiseaseAmino Acid MotifsAmino Acid SequenceAmyloid beta-Protein PrecursorAnimalsAutophagosomesBrainCarbonyl Cyanide m-Chlorophenyl HydrazoneCognition DisordersDisease Models, AnimalDown-RegulationHeLa CellsHumansMaleAmyloid beta-Protein PrecursorCarbonyl Cyanide m-Chlorophenyl HydrazoneDISC1 protein, humanDisc1 protein, mouseMAP1LC3A protein, humanMicrotubule-Associated ProteinsNerve Tissue ProteinsAlzheimer’s diseaseautophagyDisrupted-in-schizophrenia-1mitochondriamitophagy
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