Evidence map›Paper›PMID 30488641›Full record

ArticleAging cell2019

Trends in age-related disease burden and healthcare utilization.

Vincenzo Atella, Andrea Piano Mortari, Joanna Kopinska, Federico Belotti, Francesco Lapi, Claudio Cricelli, Luigi Fontana

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 211 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
211citing papers in PubMed, 9 pooled it
15.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

211 citing papers in PubMed, 9 syntheses or guidelines pooled it, 417 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Trial
  11. Trial
  12. Trial
  13. Trial
  14. Trial
  15. Patients' experiences of receiving hospital care from a mobile care unit - a qualitative interview study.International journal of qualitative studies on health and well-being · 2026
    Article
  16. Life (Basel, Switzerland) · 2026
    Review
  17. [Walkability in older age: built environment factors and function-sensitive assessment in urban areas].Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz · 2026
    Review
  18. Article
  19. Article
  20. Article

151 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Vincenzo AtellaDepartment of Economics and Finance, University of Rome "Tor Vergata", Rome, Italy.
Andrea Piano MortariCEIS Tor Vergata, University of Rome "Tor Vergata", Rome, Italy.
Joanna KopinskaCEIS Tor Vergata, University of Rome "Tor Vergata", Rome, Italy.
Federico BelottiDepartment of Economics and Finance, University of Rome "Tor Vergata", Rome, Italy.
Francesco LapiItalian College of General Practitioners (SIMG), Florence, Italy.
Claudio CricelliItalian College of General Practitioners (SIMG), Florence, Italy.
Luigi FontanaCharles Perkins Center and Central Clinical School, University of Sidney, Sidney, New South Wales.
University of Rome Tor Vergata · ITSocietà Italiana di Medicina Generale · ITStanford Health Care · USUniversity of Brescia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aging is a strong risk factor for many chronic diseases. However, the impact of an aging population on the prevalence of chronic diseases and related healthcare costs are not known. We used a prevalence-based approach that combines accurate clinical and drug prescription data from Health Search CSD-LPD. This is a longitudinal observational data set containing computer-based patient records collected by Italian general practitioners (GP) and up-to-date healthcare expenditures data from the SiSSI Project. The analysis is based on data collected by 900 GP on an unbalanced sample of more than 1 million patients aged 35+, observed in different time periods between 2005 and 2014. In 2014, 86% of the Italian adults older than 65 had at least one chronic condition, and 56.7% had two or more. Prevalence of multiple chronic diseases and healthcare utilization increased among older and younger adults between 2004 and 2014. Indeed, in the last 10 years, average number of prescriptions increased by approximately 26%, while laboratory and diagnostic tests by 27%. The average number of DDD prescribed increased with age in all the observed years (from 114 in 2005 to 119.9 in 2014 for the 35-50 age group and from 774.9 to 1,178.1 for the 81+ patients). The alarming rising trends in the prevalence of chronic disease and associated healthcare costs in Italy, as well as in many other developed countries, call for an urgent implementation of interventions that prevent or slow the accumulation of metabolic and molecular damage associated with multiple chronic disease.

Indexed as

Cost of IllnessPatient Acceptance of Health CareAdultAgedAged, 80 and overAgingChronic DiseaseComorbidityFemaleHumansMaleMiddle AgedPrevalenceagingcancercardiovascular diseasechronic diseasediabetesdisease burdenhealthcare expenditurehypertension

Identifiers

PMID30488641
PMCPMC6351821
OpenAlexW2902606100

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.