Evidence map›Paper›PMID 30488612›Full record

ArticleAmerican journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics2019

GWAS and network analysis of co-occurring nicotine and alcohol dependence identifies significantly associated alleles and network.

Bo Xiang, Bao-Zhu Yang, Hang Zhou, Henry Kranzler, Joel Gelernter

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Bo XiangDepartment of Psychiatry, Yale University School of Medicine, New Haven, Connecticut.ORCID 0000-0001-8341-2286
Bao-Zhu YangDepartment of Psychiatry, Yale University School of Medicine, New Haven, Connecticut.ORCID 0000-0001-8506-6946
Hang ZhouDepartment of Psychiatry, Yale University School of Medicine, New Haven, Connecticut.ORCID 0000-0002-7694-6391
Henry KranzlerDepartment of Psychiatry, Center for Studies of Addiction, University of Pennsylvania and VISN 4 MIRECC, Crescenz VAMC, Philadelphia, Pennsylvania.ORCID 0000-0002-1018-0450
Joel GelernterDepartment of Psychiatry, Yale University School of Medicine, New Haven, Connecticut.ORCID 0000-0002-4067-1859
Yale University · USMental Illness Research, Education and Clinical Centers · US

Funding

Translational Technologies CoreP50AA012870 · NIAAA · YALE UNIVERSITY · PI John H. Krystal · 2001 to 2026
$43.7M
Sex-specific analysis of opioid dependence GWAS and beyondR01DA012690 · NIDA · YALE UNIVERSITY · PI GELERNTER, JOEL · 2000 to 2017
$14.0M
GENETICS OF COCAINE DEPENDENCER01DA012849 · NIDA · YALE UNIVERSITY · PI GELERNTER, JOEL · 1999 to 2010
$11.5M
Linkage Disequilibrium Studies of Alcohol DependenceR01AA011330 · NIAAA · YALE UNIVERSITY · PI GELERNTER, JOEL · 1997 to 2013
$6.4M
Genomewide Association Study of Cocaine Dependence in two PopulationsRC2DA028909 · NIDA · YALE UNIVERSITY · PI GELERNTER, JOEL · 2009 to 2010
$4.2M
Genetics of Cocaine DependenceR01DA018432 · NIDA · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI KRANZLER, HENRY RICHARD · 2006 to 2010
$3.5M
Genetics of Alcohol Dependence in African-AmericansR01AA017535 · NIAAA · YALE UNIVERSITY · PI GELERNTER, JOEL · 2009 to 2013
$3.0M
GENOTYPING FOR LOCATING HUMAN DISEASE GENESN01HG065403 · NHGRI · JOHNS HOPKINS UNIVERSITY · PI VALLE, DAVID L · 1996 to 2000
$1.7M
Mapping Genes for comorbidity of SUDs and DepressionK01DA024758 · NIDA · YALE UNIVERSITY · PI YANG, BAO-ZHU · 2008 to 2012
$849k
China Scholarship CouncilNHGRI NIH HHS N01 HG065403NIAAA NIH HHS P50 AA012870NIAAA NIH HHS R01 AA011330NIAAA NIH HHS R01 AA017535NIDA NIH HHS K01 DA024758NIDA NIH HHS R01 DA012690NIDA NIH HHS R01 DA012849NIDA NIH HHS R01 DA018432NIDA NIH HHS RC2 DA028909NIH HHS N01-HG-65403NIH HHS P50 AA12870NIH HHS R01 AA017535NIH HHS R01 AA11330NIH HHS R01 DA18432NIH HHS RC2 DA028909NIMH NIH HHS R01 DA12690NIMH NIH HHS R01 DA12849NIMH NIH HHS R01 DA1843NIMH NIH HHS RC2 DA028909US Veterans Affairs Connecticut and Veterans Affairs Philadelphia Mental Illness Research, Education and Clinical CentersVA Medical Research Service
6 · The paper itself

Abstract

Alcohol dependence (AD) and nicotine dependence (ND) co-occur frequently (AD+ND). We integrated SNP-based, gene-based, and protein-protein interaction network analyses to identify shared risk genes or gene subnetworks for AD+ND in African Americans (AAs, N = 2,094) and European Americans (EAs, N = 1,207). The DSM-IV criterion counts for AD and ND were modeled as two dependent variables in a multivariate linear mixed model, and analyzed separately for the two populations. The most significant SNP was rs6579845 in EAs (p < 1.29 × 10

Indexed as

AdultAlcoholismAllelesBlack or African AmericanComorbidityEthanolFemaleGene FrequencyGene Regulatory NetworksGenetic Predisposition to DiseaseGenome-Wide Association StudyG(M2) Activator ProteinHumansMaleMiddle AgedNicotineEthanolG(M2) Activator ProteinNicotinealcohol dependence co-occurring nicotine dependencegenome-wide association studiesnetwork analysispleiotropy

Identifiers

PMID30488612
PMCPMC6918694
OpenAlexW2903203327

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.