Evidence map›Paper›PMID 30488599›Full record

ArticleAngewandte Chemie (International ed. in English)2019

Divergent Synthesis of Natural Derivatives of (+)-Saxitoxin Including 11-Saxitoxinethanoic Acid.

James R Walker, Jeffrey E Merit, Rhiannon Thomas-Tran, Doris T Y Tang, J Du Bois

Abstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Saxiphilin is a broad-spectrum toxin sponge for C13-modified saxitoxins.bioRxiv : the preprint server for biology · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Discovery of Selective Inhibitors of NaACS medicinal chemistry letters · 2022
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

James R WalkerSAFC, Inc., 645 Science Dr., Madison, WI, 53711, USA.
Jeffrey E MeritGilead Sciences, 333 Lakeside Dr., Foster City, CA, 94404, USA.
Rhiannon Thomas-TranArcus Biosciences, Inc., 3928 Point Eden Way, Hayward, CA, 94545, USA.
Doris T Y TangDepartment of Chemistry, Stanford University, Stanford, CA, 94305, USA.ORCID 0000-0001-9178-7811
J Du BoisDepartment of Chemistry, Stanford University, Stanford, CA, 94305, USA.ORCID 0000-0001-7847-1548
Stanford University · USGilead Sciences (United States) · USPulse Biosciences (United States) · USSubstance Abuse Free Environment · US

Funding

Guanidinium Toxins as Molecular Probes for NaV StudyR01GM117263 · NIGMS · STANFORD UNIVERSITY · PI DU BOIS, JUSTIN · 2016 to 2024
$3.5M
NIGMS NIH HHS R01 GM117263
6 · The paper itself

Abstract

The bis-guanidinium toxins are a collection of natural products that display nanomolar potency against select isoforms of eukaryotic voltage-gated Na

Indexed as

Biological ProductsMolecular StructureSaxitoxinStereoisomerism11-saxitoxinethanoic acidBiological ProductsSaxitoxinguanidinium toxinsrearrangementsodium channelsStille couplingsulfoxide

Identifiers

PMID30488599
PMCPMC6426452
OpenAlexW2902955820

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.