Evidence map›Paper›PMID 30488584›Full record

ArticleHLA2019

HLA-B*44:138Q: Evidence for a confined deletion and recombination events in an otherwise unaffected HLA-haplotype.

Ingrid Faé, Sabine Wenda, Cornelia Grill, Gottfried F Fischer

Abstract read
In one paragraph

Article in HLA, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Early progression of chronic histologic lesions in kidney transplant biopsies is not associated with HLA histocompatibility.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2024
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ingrid FaéDepartment for Blood Group Serology and Transfusion Medicine, Medical University of Vienna, Vienna, Austria.
Sabine WendaDepartment for Blood Group Serology and Transfusion Medicine, Medical University of Vienna, Vienna, Austria.
Cornelia GrillDepartment for Blood Group Serology and Transfusion Medicine, General Hospital of Vienna, Vienna, Austria.
Gottfried F FischerDepartment for Blood Group Serology and Transfusion Medicine, Medical University of Vienna, Vienna, Austria.ORCID 0000-0002-3442-3680

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We discovered a new HLA-B allele, HLA-B*44:138Q, and confirmed its segregation. For characterisation, we used serology, sequence specific oligonucleotide (SSO), sequence specific primer (SSP), and full length sequencing by Sanger and next-generation sequencing. From an evolutionary point the 5' part of the new allele is identical with alleles from the HLA-B*44:02 group, while its 3' part is identical to the HLA-B*15:18:01:02 allele, the breakpoint being located somewhere between intron 3 and exon 4. The salient feature of the new allele is a deletion of codon 94 in exon 3, which is unique for HLA-alleles reported so far. Gene conversion can be hypothesised in the generation of this HLA sequence; however, the deletion seems to have occurred additionally. Other HLA-alleles of the new allele's haplotype were common alleles.

Indexed as

Gene DeletionRecombination, GeneticBase SequenceFemaleHaplotypesHLA-B AntigensHumansMalePedigreeHLA-B Antigens

Identifiers

PMID30488584
PMCPMC6590401

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.