ReviewImmunology2019
Basics of memory B-cell responses: lessons from and for the real world.
Review in Immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed.
- Novel Sarcoidosis Epitope Augments MHCII, CD80, and CD86 Expression and Promotes B-Cell Differentiation and IgG Production.American journal of respiratory cell and molecular biology · 2025Article
- Memory Cells in Infection and Autoimmunity: Mechanisms, Functions, and Therapeutic Implications.Vaccines · 2025Review
- A consensus mathematical model of vaccine-induced antibody dynamics for multiple vaccine platforms and pathogens.Frontiers in immunology · 2025Article
- Glioblastoma microenvironment-from biology to therapy.Genes & development · 2024Review
- Feasibility of Using a Type I IFN-Based Non-Animal Approach to Predict Vaccine Efficacy and Safety Profiles.Vaccines · 2024Review
- mRNA-LNP prime boost evolves precursors toward VRC01-like broadly neutralizing antibodies in preclinical humanized mouse models.Science immunology · 2024Article
- Characterization of humoral and cellular immunologic responses to an mRNA-based human cytomegalovirus vaccine from a phase 1 trial of healthy adults.Journal of virology · 2024Article
- Isotype switching in human memory B cells sets intrinsic antigen-affinity thresholds that dictate antigen-driven fates.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Article
- Atypical memory B cell frequency correlates with antibody breadth and function in malaria immune adults.Scientific reports · 2024Article
- Revitalize splenic functions. Following a splenectomy for trauma, a small amount of splenic autotransplantation was performed.BMC surgery · 2023Article
- Efficient antigen delivery by dendritic cell-targeting peptide via nucleolin confers superior vaccine effects in mice.iScience · 2022Article
- Effects of the age of vaccination on the humoral responses to a human papillomavirus vaccine.NPJ vaccines · 2022Article
- H3K36 methyltransferase NSD1 is essential for normal B1 and B2 cell development and germinal center formation.Frontiers in immunology · 2022Article
- Surface phenotypes of naive and memory B cells in mouse and human tissues.Nature immunology · 2022Article
- Review
- High-affinity memory B cells induced by SARS-CoV-2 infection produce more plasmablasts and atypical memory B cells than those primed by mRNA vaccines.Cell reports · 2021Article
- Affinity-Restricted Memory B Cells Dominate Recall Responses to Heterologous Flaviviruses.Immunity · 2020Article
- Antibody Responses to SARS-CoV-2: Let's Stick to Known Knowns.Journal of immunology (Baltimore, Md. : 1950) · 2020Review
- Japanese encephalitis virus infection in non-encephalitic acute febrile illness patients.PLoS neglected tropical diseases · 2020Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The production of pathogen-specific B cells and antibodies underlies protective immunity elicited by most vaccines and many infections. Humoral immunity follows a regulated process by which high-affinity antibody-secreting plasma cells and memory B cells are generated. Yet for certain pathogens, protective immunity is inefficiently generated and/or maintained. For example, Dengue virus infections lead to lasting immunity against re-infection by the same serotype. However, if infected with a different Dengue serotype, the individual is predisposed to more severe disease than if he/she was completely naive. As another example, both natural infections with or vaccination against malaria do not necessarily lead to lasting immunity, as the same individual can be re-infected many times over the course of a lifetime. In this review, we discuss how these real-world problems can both instruct and be informed by recent basic studies using model organisms and antigens. An emphasis is placed on protective epitopes and functional distinctions between memory B-cell subsets in both mice and humans. Using flavivirus and Plasmodium infections as examples, we also speculate on the differences between ineffective B-cell responses that actually occur in the real world, and perfect-world responses that would generate lasting immunity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.