Evidence map›Paper›PMID 30488473›Full record

ArticlePrenatal diagnosis2019

A new biometric: In utero growth curves for metacarpal and phalangeal lengths reveal an embryonic patterning ratio.

Rashmi Rao, Jeffrey Gornbein, Yalda Afshar, Lawrence D Platt, Greggory R DeVore, Deborah Krakow

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Prenatal diagnosis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 85% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Rashmi RaoObstetrics and Gynecology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Jeffrey GornbeinDepartment of Biomathematics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Yalda AfsharObstetrics and Gynecology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Lawrence D PlattObstetrics and Gynecology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Greggory R DeVoreObstetrics and Gynecology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.ORCID 0000-0001-8814-572X
Deborah KrakowDepartment of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.ORCID 0000-0001-9906-4968
University of California, Los Angeles · US

Funding

Unraveling the mechanisms of prenatal-onset disorders affecting the skeletonR01AR066124 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KRAKOW, DEBORAH · 2014 to 2018
$1.7M
Rare Diseases Clinical Research Scholar’s ProgramR25HD078229 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI REGIER, DEBRA S, SUMMAR, MARSHALL L · 2015 to 2020
$528k
NIAMS NIH HHS R01 AR066124NICHD NIH HHS R25 HD078229NIH HHS R25 HD078229
6 · The paper itself

Abstract

objectivesThe objectives of this study are to develop gestational age-specific growth curves for fetal third metacarpal and phalangeal lengths and to determine if fetal hand proportion is established in utero.

methodsThis prospective cross-sectional study used 2D ultrasound across gestational ages 12 to 39 weeks to evaluate the third fetal metacarpal and phalangeal measurements. Gestational age-specific reference growth curves were developed. Associations between continuous variables were assessed using Spearman correlations (r

resultsFetal metacarpal and phalangeal lengths are highly correlated across gestational age (r

conclusionWe present gestational age-specific reference growth curves for fetal third metacarpal and phalangeal lengths, which may be used to detect brachydactyly. We demonstrate a prenatal metacarpal to phalangeal ratio of 1:2.

Indexed as

Body PatterningGrowth ChartsAdultBiometryCross-Sectional StudiesFemaleFinger PhalangesGestational AgeHumansMetacarpal BonesPregnancyProspective Studies

Identifiers

PMID30488473
PMCPMC8805676
OpenAlexW2902174464

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.