Evidence map›Paper›PMID 30488455›Full record

ArticleMedical physics2019

Nonstationary model of oblique x-ray incidence in amorphous selenium detectors: II. Transfer functions.

Raymond J Acciavatti, Andrew D A Maidment

Open access · greenAbstract read
In one paragraph

Article in Medical physics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Radiation Detectors and Sensors in Medical Imaging.Sensors (Basel, Switzerland) · 2024
    Review
  2. Article
  3. Proposing Rapid Source Pulsing for Improved Super-Resolution in Digital Breast Tomosynthesis.Proceedings of SPIE--the International Society for Optical Engineering · 2020
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Raymond J AcciavattiDepartment of Radiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 19104-4206, USA.
Andrew D A MaidmentDepartment of Radiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 19104-4206, USA.
University of Pennsylvania · US

Funding

High Performance, Quantitative Breast PET Scanner Integrated With TomosynthesisR01CA196528 · NCI · UNIVERSITY OF PENNSYLVANIA · PI ANDREW DOUGLAS ARNOLD MAIDMENT, Suleman Surti · 2016 to 2026
$5.9M
Training Program in Biomedical Imaging and Information SciencesT32EB009384 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI GEE, JAMES C, IVES, ZACHARY · 2009 to 2023
$4.0M
Virtual Clinical Trials: Simulation of Digital Breast Tomosynthesis ScreeningR01CA154444 · NCI · UNIVERSITY OF PENNSYLVANIA · PI MAIDMENT, ANDREW DOUGLAS ARNOLD · 2011 to 2014
$2.3M
Burroughs Wellcome Fund IRSA 1016451Department of Defense Breast Cancer Research Program W81XWH-18-1-0082NCI NIH HHS 1R01CA154444NCI NIH HHS 1R01CA196528NCI NIH HHS R01 CA154444NCI NIH HHS R01 CA196528NIBIB NIH HHS T32 EB009384Susan G. Komen® IIR13264610Susan G. Komen® PDF14302589
6 · The paper itself

Abstract

purposeOne limitation of experimental techniques for quantifying resolution and noise in detectors is that the measurement is made in a region-of-interest (ROI). With theoretical modeling, these properties can be measured at a point, allowing for quantification of spatial anisotropy. This paper calculates nonstationary transfer functions for amorphous selenium (a-Se) detectors in breast imaging. We use this model to demonstrate the performance advantage of a "next-generation" tomosynthesis (NGT) system, which is capable of x-ray source motion with more degrees of freedom than a clinical tomosynthesis system.

methodsUsing Swank's formulation, the optical transfer function (OTF) and presampled noise power spectra (NPS) are determined based on the point spread function derived in Part 1. The modulation transfer function (MTF) is found from the normalized modulus of the OTF. To take into account the presence of digitization, the presampled NPS is convolved with a two-dimensional comb function, for which the period along each direction is the reciprocal of the detector element size. The detective quantum efficiency (DQE) is then determined from combined knowledge of the OTF and NPS.

resultsFirst, the model is used to demonstrate the loss of image quality due to oblique x-ray incidence. The MTF is calculated along various polar angles, corresponding to different orientations of the input frequency. The MTF is independent of the incidence angle if the polar angle is perpendicular to the ray incidence direction. However, along other polar angles, oblique incidence results in MTF degradation at high frequencies. The MTF degradation is most substantial along the ray incidence direction. Unlike the MTF, the normalized NPS (NNPS) is independent of the incidence angle. To measure the relative signal-to-noise, the DQE is also calculated. Oblique incidence yields high-frequency DQE degradation, which is more pronounced than the MTF degradation. This arises because the DQE is proportionate with the square of the MTF. Ultimately, this model is used to evaluate how the image quality varies over the detector area. For various projection images, we calculate the variation in the incidence angle over this area. With the NGT system, the source can be positioned in such a way that this variation is minimized, and hence the DQE exhibits less anisotropy. To achieve this improvement in the image quality, the source needs to have a component of motion in the posteroanterior (PA) direction, which is perpendicular to the conventional direction of source motion in tomosynthesis.

conclusionsIn a-Se detectors, the DQE at high frequencies is degraded due to oblique incidence. The DQE degradation is more pronounced than the MTF degradation. This model is used to quantify the spatial variation in DQE over the detector area. The use of PA source motion is a strategy for minimizing this variation and thus improving the image quality.

Indexed as

Models, TheoreticalSeleniumRadiographyX-RaysSeleniumamorphous seleniumdetective quantum efficiency (DQE)digital x-ray detectorsmodulation transfer function (MTF)obliquity effect

Identifiers

PMID30488455
PMCPMC6502710
OpenAlexW2903061308

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.