ArticleJournal of cardiovascular translational research2019
Comparative Quantification of Arterial Lipid by Intravascular Photoacoustic-Ultrasound Imaging and Near-Infrared Spectroscopy-Intravascular Ultrasound.
Article in Journal of cardiovascular translational research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The trial behind it
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Who cites it
12 citing papers in PubMed.
- From intravascular imaging to adaptive vascular care: intelligent photonics and digital twins in panvascular disease.Light, science & applications · 2026Review
- High-speed multimodal intravascular ultrasound and photoacoustic imaging system for atherosclerosis characterization.Biomedical optics express · 2026Article
- Dual-modal Photoacoustic and Ultrasound Imaging: from preclinical to clinical applications.Frontiers in photonics · 2024Article
- A high-sensitivity high-resolution intravascular photoacoustic catheter through mode cleaning in a graded-index fiber.Photoacoustics · 2023Article
- Intra-instrument channel workable, optical-resolution photoacoustic and ultrasonic mini-probe system for gastrointestinal endoscopy.Photoacoustics · 2022Article
- Clinical photoacoustic/ultrasound dual-modal imaging: Current status and future trends.Frontiers in physiology · 2022Review
- In vivo safety study using radiation at wavelengths and dosages relevant to intravascular imaging.Journal of biomedical optics · 2022Article
- IVUS\IVPA hybrid intravascular molecular imaging of angiogenesis in atherosclerotic plaquesPhotoacoustics · 2021Article
- Photoacoustic Imaging of Human Vasculature Using LED versus Laser Illumination: A Comparison Study on Tissue Phantoms and In Vivo Humans.Sensors (Basel, Switzerland) · 2021Article
- Highly sensitive lipid detection and localization in atherosclerotic plaque with a dual-frequency intravascular photoacoustic/ultrasound catheter.Translational biophotonics · 2020Article
- Label-free photoacoustic and ultrasound imaging for murine atherosclerosis characterization.APL bioengineering · 2020Article
- Perivascular Adipose Tissue as an Indication, Contributor to, and Therapeutic Target for Atherosclerosis.Frontiers in physiology · 2020Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Intravascular photoacoustic-ultrasound (IVPA-US) imaging and near-infrared spectroscopy-intravascular ultrasound (NIRS-IVUS) are two hybrid modalities that detect arterial lipid, with comparison necessary to understand the relative advantages of each. We performed in vivo and ex vivo IVPA-US imaging of the iliac arteries of Ossabaw swine with metabolic syndrome (MetS) and lean swine to investigate sensitivity for early-stage atherosclerosis. We repeated imaging ex vivo with NIRS-IVUS for comparison to IVPA-US and histology. Both modalities showed significantly greater lipid in MetS vs. lean swine, but only IVPA-US localized the lipid as perivascular. To investigate late-stage atherosclerosis, we performed ex vivo IVPA-US imaging of a human coronary artery with comparison to NIRS-IVUS and histology. Two advanced fibroatheromas were identified, with agreement between IVPA-measured lipid area and NIRS-derived lipid content. As confirmed histologically, IVPA-US has sensitivity to detect lipid content similar to NIRS-IVUS and provides additional depth resolution, enabling quantification and localization of lipid cores within plaques.
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