Evidence map›Paper›PMID 30488317›Full record

ArticleNatural products and bioprospecting2019

Synthesis, Urease Inhibition and Molecular Modelling Studies of Novel Derivatives of the Naturally Occurring β-Amyrenone.

Jean J K Bankeu, Hira Sattar, Yannick S F Fongang, Syeda W Muhammadi, Conrad V Simoben, Fidele Ntie-Kang, Guy R T Feuya, Marthe A T Tchuenmogne, Mehreen Lateef, Bruno N Lenta and 2 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Natural products and bioprospecting, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 4 countries.

Jean J K BankeuDepartment of Chemistry, Faculty of Science, The University of Bamenda, P.O. Box 39, Bambili, Cameroon. bk_jeanjules@yahoo.fr.ORCID http://orcid.org/0000-0001-8483-6080
Hira SattarInternational Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan.
Yannick S F FongangInternational Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan.
Syeda W MuhammadiInternational Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan.
Conrad V SimobenDepartment of Pharmaceutical Chemistry, Martin-Luther University of Halle-Wittenberg, Wolfgang-Langenbeck-Str. 4, 06120, Halle (Saale), Germany.
Fidele Ntie-KangDepartment of Pharmaceutical Chemistry, Martin-Luther University of Halle-Wittenberg, Wolfgang-Langenbeck-Str. 4, 06120, Halle (Saale), Germany. ntiekfidele@gmail.com.
Guy R T FeuyaDepartment of Chemistry, Faculty of Science, Scientific and Technical University of Masuku, Box 943, Franceville, Gabon.
Marthe A T TchuenmogneDepartment of Chemistry, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon.
Mehreen LateefMulti-Disciplinary Research Laboratory (MDRL), Bahria University Medical and Dental College, Bahria University, Karachi, Pakistan.
Bruno N LentaDepartment of Chemistry, Higher Teacher Training College, University of Yaoundé I, P.O. Box 47, Yaoundé, Cameroon. lentabruno@yahoo.fr.
Muhammad S AliInternational Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan.
Augustin S NgouelaDepartment of Chemistry, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon.
University of Karachi · PKUniversité de Yaoundé I · CMBahria University · PKMartin Luther University Halle-Wittenberg · DEUniversité des Sciences et Techniques de Masuku · GAUniversity of Buea · CM

Funding

ICCBS-TWAS Postdoctoral Fellowship 3240280476
6 · The paper itself

Abstract

Urease enzyme (UE) has been reported to be a potent virulence factor for Helicobacter pylori (HP) bacteria indicated to be responsible for various gastrointestinal diseases. Therefore, the spread of HP, currently regarded by the World Health Organization as a class 1 carcinogen, could be better controlled by targeting UE. It is in this line that we have synthesized three new derivatives (2-4) of the naturally occurring olean-12-en-3-one (1), which was previously isolated from the figs of Ficus vallis-choudae Delile (Moraceae). Among the synthesized compounds, 3 and 4 contain an indole moiety. Their structures were unambiguously assigned by spectroscopic and spectrometric techniques (1D-NMR, 2D-NMR and MS). The starting material and the synthesized compounds were screened for UE inhibition activity, and showed significant activities with IC

Indexed as

DockingHelicobacter pyloriOlean-12-en-3-one derivativesUrease inhibition

Identifiers

PMID30488317
PMCPMC6328428
OpenAlexW2903080405

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.