Evidence map›Paper›PMID 30488265›Full record

ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2019

Micropulse laser trabeculoplasty on pseuodexfoliation glaucoma patients under topical prostaglandin analogue monotherapy: 1-year results.

Olga E Makri, Athina Pallikari, Dionysios Pagoulatos, Konstantinos Kagkelaris, Elli V Kostopoulou, Constantinos D Georgakopoulos

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03483402 (Study of the Efficacy of a Single Session Micropulse Laser Trabeculoplasty as an Adjunctive Measure in Decreasing Intraocular Pressure in Patients Suffering From Pseudoexfoliation Glaucoma), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03483402 nacompletednot on this map

Study of the Efficacy of a Single Session Micropulse Laser Trabeculoplasty as an Adjunctive Measure in Decreasing Intraocular Pressure in Patients Suffering From Pseudoexfoliation Glaucoma

TypeinterventionalSponsorUniversity Hospital of PatrasRan2016 to 2018Enrolled27ConditionsPseudoexfoliation Glaucoma, Primary Open-angle GlaucomaArmsMicropulse laser trabeculoplasty
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Olga E MakriDepartment of Ophthalmology, University of Patras, Medical School, 265 04, Patras, Greece.
Athina PallikariDepartment of Ophthalmology, University of Patras, Medical School, 265 04, Patras, Greece.
Dionysios PagoulatosDepartment of Ophthalmology, University of Patras, Medical School, 265 04, Patras, Greece.
Konstantinos KagkelarisDepartment of Ophthalmology, University of Patras, Medical School, 265 04, Patras, Greece.
Elli V KostopoulouDepartment of Ophthalmology, University of Patras, Medical School, 265 04, Patras, Greece.
Constantinos D GeorgakopoulosDepartment of Ophthalmology, University of Patras, Medical School, 265 04, Patras, Greece. cgeorg@upatras.gr.ORCID http://orcid.org/0000-0002-5646-1370
University of Patras · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the effectiveness of a single session of micropulse laser trabeculoplasty (MLT) to lower intraocular pressure (IOP) in patients with pseudoexfoliation glaucoma (PEXG).

methodsIn this single-center, one-arm, prospective study patients with PEXG under prostaglandine analogue monotherapy with inadequate IOP control were treated with 360° 532-nm MLT. Patients were evaluated at 1 day, 1 month, 3 months, 6 months, and 12 months post-MLT while they were treated with the same drug regimen as pre-MLT. Mean IOP reduction and percentage of IOP change during the follow-up were calculated. Cases that required any further intervention, like additional hypotensive medication, laser or surgical therapy, throughout the study period were considered failures and removed from the study.

resultsTwenty-seven eyes (27 patients, 17 male) were included in the study. The age of the patients was 72.37 ± 6.29 years and the baseline IOP was 20.41 ± 1.87 mmHg. Treatment with MLT resulted in significantly lower IOP at 1, 3, 6, and 12 months after MLT compared to baseline (p < 0.0001 for all comparisons). By the end of the study, 52.17% of the PEXG eyes demonstrated a ≥ 20% IOP reduction compared to baseline. Four eyes (14.81%) did not respond to MLT (three eyes at 3 months and one eye at 6 months after trabeculoplasty) and were considered failures since they required additional intervention.

conclusionsMicropulse laser trabeculoplasty appears to be an effective method to lower IOP in patients with PEXG up to 12 month of follow-up period.

trial registrationThe study is registered on www.ClinicalTrials.gov with registration number NCT03483402.

Indexed as

AgedExfoliation SyndromeFemaleFollow-Up StudiesHumansIntraocular PressureLaser TherapyMaleOphthalmic SolutionsProspective StudiesProstaglandins, SyntheticTime FactorsTrabeculectomyTreatment OutcomeOphthalmic SolutionsProstaglandins, SyntheticIntraocular pressureMicropulse laserPseudoexfoliation glaucomaTrabeculoplasty

Identifiers

PMID30488265
OpenAlexW2903235304

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.