ArticleDigestive diseases and sciences2019
Epidemiology of Whipple's Disease in the USA Between 2012 and 2017: A Population-Based National Study.
Article in Digestive diseases and sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 66 citations in OpenAlex.
- Whipple's endocarditis and biologic response modifiers: a case-based review of an intricate host-pathogen interaction.Infection · 2026Review
- Prevalence, characteristics, and clinical outcomes of Whipple disease in patients initially diagnosed with a rheumatic disease: a large nested case-control study in the Eastern Netherlands.EULAR rheumatology open · 2026Article
- Whipple's disease with multiple serous effusions as the clinical manifestation: a case report and literature review.Infectious diseases of poverty · 2026Review
- Rare but Critical: SevereClinical case reports · 2026Article
- Deciphering whipple's disease complexity.Clinical and experimental medicine · 2026Review
- Clinical characteristics ofIDCases · 2026Article
- A case of pulmonary nodular lesion caused by Tropheryma whipplei infection: a case report and literature review.BMC pulmonary medicine · 2025Review
- Interplay of multiple neurological conditions - the first case of neurological Whipple's disease in Syria: a case report.Annals of medicine and surgery (2012) · 2025Article
- Whipple's disease in southern New Brunswick, Canada: A case series.Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada · 2025Article
- A Family at War-AgainstOpen forum infectious diseases · 2025Article
- Tropheryma whipplei Infections, Mexico, 2019-2021.Emerging infectious diseases · 2025Article
- Eyelid abscess as an initial manifestation of whipple's disease: a case report and comprehensive literature review.BMC ophthalmology · 2025Review
- Central nervous system involvement in Whipple's disease: Report of a rare pathological entity and comparative review of treatment strategies and outcomes.Radiology case reports · 2025Article
- Supranuclear Vertical Gaze Palsy in Movement Disorders.Neuro-ophthalmology (Aeolus Press) · 2025Review
- Clinical Features of Patients withInfection and drug resistance · 2025Article
- Article
- Whipple Disease Presenting as Isolated Transverse Myelitis with Permanent Neurological Damage in a Patient with Systemic Lupus Erythematosus: A Case Report of a Difficult Diagnosis with a Literature Review.Infectious disease reports · 2024Article
- A 40-Year-Old Man with a 7-Year History of Polyarthritis and a Late Diagnosis of Whipple Disease: A Journey to Resolve the Mystery.The American journal of case reports · 2024Article
- Short-Term Amoxicillin Clavulanate in the Treatment of Pulmonary Abscess Caused byInfection and drug resistance · 2024Article
- Use of bevacizumab in a patient with Whipple's disease: managing diagnostic uncertainty.BMJ case reports · 2023Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
objectivePrior studies on the epidemiology of Whipple's disease are limited by small sample size and case series design. We sought to characterize the epidemiology of Whipple's disease in the USA utilizing a large population-based database.
methodsWe queried a commercial database (Explorys Inc, Cleveland, OH), an aggregate of electronic health record data from 26 major integrated healthcare systems in the USA. We identified a cohort of patients with a diagnosis of Whipple's disease based on systemized nomenclature of medical terminology (SNOMED CT) codes. We calculated the overall and age-, race-, ethnicity, and gender-based prevalence of Whipple's disease and prevalence of associated diagnoses using univariate analysis.
resultsA total of 35,838,070 individuals were active in the database between November 2012 and November 2017. Of these, 350 individuals had a SNOMED CT diagnosis of Whipple's disease, with an overall prevalence of 9.8 cases per 1 million. There was no difference in prevalence based on sex. However, prevalence of Whipple's disease was higher in Caucasians, non-Hispanics, and individuals > 65 years old. Individuals with a diagnosis of Whipple's disease were more likely to have associated diagnoses/findings of arthritis, CNS disease, endocarditis, diabetes, malignancy, dementia, vitamin D deficiency, iron deficiency, chemotherapy, weight loss, abdominal pain, and lymphadenopathy.
conclusionsTo our knowledge, this is the largest study to date examining the epidemiology of Whipple's disease. In this large population-based study, the overall prevalence of Whipple's disease in the USA is 9.8 cases per 1 million people. It affects men and women at similar rates and is more common in Caucasians, non-Hispanics, and people > 65 years old.
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