ArticleJournal of neurology2019
Incidence of Parkinson's disease in a large patient cohort with idiopathic smell and taste loss.
Article in Journal of neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 2 of them syntheses that pooled it.
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Who cites it
61 citing papers in PubMed, 2 syntheses or guidelines pooled it, 107 citations in OpenAlex.
- Does glitazone treatment have a role on the prevention of Parkinson's disease in adult diabetic population? A systematic review.Metabolic brain disease · 2020Pooled it
- Hyposmia as a Predictive Marker of Parkinson's Disease: A Systematic Review and Meta-Analysis.BioMed research international · 2019Pooled it
- Correlating symptoms and skin α-synuclein seeding parameters in olfactory dysfunction and Lewy body dementia.Journal of neurology · 2026Article
- Diagnostics of olfactory dysfunction in Parkinson's disease - a literature overview and case series.Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia · 2026Review
- Prodromal Lewy Body Symptoms and α-Synuclein Seeding in Idiopathic Olfactory Dysfunction.Movement disorders clinical practice · 2026Article
- Evaluation of idiopathic olfactory dysfunction as a warning marker for early parkinson's disease: a population-based cross-sectional study.Scientific reports · 2026Article
- Novel Gene-Informed Regional Brain Targets for Clinical Screening for Major Depression.Neurology international · 2025Article
- Motor Cortex Disinhibition Correlates with Olfactory Dysfunction in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Olfactory training enhances semantic verbal fluency in healthy older adults, but only for individuals with low baseline performance.Chemical senses · 2025Article
- Facets of movement disorders- a tribute to Heinz Reichmann.Journal of neural transmission (Vienna, Austria : 1996) · 2024Article
- Effects of preoperative neoadjuvant chemotherapy on postoperative delirium in patients with gynecological tumor surgery: an observational study.Journal of cancer research and clinical oncology · 2024Observational
- Microbiota Orchestra in Parkinson's Disease: The Nasal and Oral Maestros.Biomedicines · 2024Review
- Characteristics of higher depressive tendency in the patients with olfactory disorder.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024Article
- Hyposmia correlates with axial signs and gait disorder in Parkinson's disease: an Italian Olfactory Identification Test study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Disrupted Brain Network Measures in Parkinson's Disease Patients with Severe Hyposmia and Cognitively Normal Ability.Brain sciences · 2024Article
- Correlations between Gustatory, Olfactory, Cognitive Function, and Age in Healthy Women.Nutrients · 2024Article
- Novel Variants Linked to the Prodromal Stage of Parkinson's Disease (PD) Patients.Diagnostics (Basel, Switzerland) · 2024Article
- Parkinson's Disease and Photobiomodulation: Potential for Treatment.Journal of personalized medicine · 2024Review
- The greatest loss of unpleasant smells may be related to the risk of more severe PD symptoms.Frontiers in neurology · 2024Article
- Opportunities and Pitfalls of REM Sleep Behavior Disorder and Olfactory Dysfunction as Early Markers in Parkinson's Disease.Journal of Parkinson's disease · 2024Review
1 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPatients with idiopathic smell loss constitute an at-risk population for the development of Parkinson's disease (PD). The study aimed to follow up a large number of patients with idiopathic smell and/or taste loss to define the incidence of PD in this population and, further, to assess characteristics of both olfactory and gustatory function and their possible association with PD development.
methodsIn this prospective case-control study, 833 patients diagnosed with an idiopathic smell disorder at our Smell and Taste Center during the last 15 years were contacted for a telephone interview. In 474 patients, a complete data set containing of demographic data, clinical information, retrospective smell and taste testing results, and telephone assessment was obtained.
resultsOut of 474 patients with idiopathic smell loss 45 (9.8%) had been diagnosed with PD, since they received the diagnosis of idiopathic smell and/or taste loss (mean 10.9 years after olfactory loss onset). Thus, with respect to the classification into olfactory/gustatory disorders, 28.6% of the patients with a combined olfactory and gustatory disorder developed PD, whereas in 9.9% of those with a pure olfactory disorder and in 3.8% of those with a pure gustatory disorder, PD was diagnosed. No association emerged between qualitative smell or taste loss and PD development.
conclusionThis large patient cohort study extends the previous literature, indicating that risk stratification might be considerably improved by correct diagnostic allocation and emphasizes the need for an exhaustive olfactory and gustatory assessment in specialized centers.
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